Synthesis of 1,2,3-Triazole-Fused Heterocycles via Intramolecular Azide-Alkyne Cycloaddition Reactions

摘要

This brief review article describes the progress made in the synthesis of 1,2,3-triazole-fused heterocycles, over the last ten years, mainly by azide-alkyne cycloaddition reactions. In this article, the emphasis is on the various aspects of 1,3-dipolar cycloaddition reactions, especially intramolecular azide-alkyne dipolar cycloaddition reactions. 1 Introduction 2 Synthesis of Fused Triazoles 2.1 Synthesis of 1,2,3-Triazole-Fused Heterocycles by Huisgen (Thermal) 1,3 -Cycloaddition Reactions 2.2 Microwave-Assisted 1,3-Dipolar Cycloaddition Reactions for the Synthesis of Condensed Triazoles 2.3 Copper-Catalyzed Cycloaddition Reactions for the Synthe sis of Condensed Triazoles 2.4 Copper/Other-Metal-Catalyzed Cycloaddition Reactions for the Synthesis of Condensed Triazoles 2.5 Synthesis of Triazole-Containing Macrocycles by Azide-Alkyne 1,3-Dipolar Cycloaddition Reactions 3 Conclusion.