Synthesis of 1,2-dimetallic compounds via direct insertion of zinc powder in the presence of InCl3: Synthesis of ortho-bis-functionalized aromatics

摘要

A variety of functionalized 1,2-dizinc reagents can be prepared by an indium-catalyzed insertion of zinc powder into aromatic 1,2-dibromides or 1-bromo-2-triflates. These 1,2-dimetallics undergo Cu- or Pd-catalyzed acylations, allylations, or cross couplings.