Chiral squaramide catalyzed asymmetric conjugate additions of 3-substituted oxindoles to vinylphosphonates

摘要

An efficient organocatalytic enantioselective conjugate addition of 3-substituted oxindoles to activated vinylphosphonates has been described. This reaction allows the facile synthesis of a new family of organophosphorus derivatives bearing an oxindole motif in high chemical yields with good to excellent stereoselectivities.