Antibiofilm Activity of Zinc-Carbonate Hydroxyapatite Nanocrystals Against Streptococcus mutans and Mitis Group Streptococci

摘要

Dental plaque is a complex multispecies biofilm consisting of a dense community of interacting bacteria (~1010 cells/mg) embedded in a self-produced polysaccharide matrix [1, 4]. Plaque control is critical for oral health, since plaque bacteria include pathogens involved in both dental caries and periodontal disease—the most prevalent human microbial diseases—in addition to a variety of opportunistic pathogens that cause endocarditis, bacteraemia and septicaemia [10].