Synthesis of 2,4-bis(aryloxy)-1,5-diarylpentane-1,5-diones by base-mediated tandem reaction

摘要

A new, practical, base-mediated method has been developed for the synthesis of 2,4-bis(aryloxy)-1,5-diarylpentane-1,5-diones by a tandem α-methylenation-Michael reaction through activation of two C-Cl bonds. This method permits the use of dichloromethane instead of dibromomethane as a source of one carbon atom for the α-methylenation reaction. The products are useful in syntheses of polysubstituted pyridines and methylenebisbenzofurans.