Cyclization of Bifunctional 3,5-Diamino-l//-l,2,4-triazole-l-carboximid-amide, 5-Amino-3-hydrazinotriazole and 3,6-Diguanidino-l,2,4,5-tetrazine: A One-Step Route to Fluorinated Heteropolycycles

摘要

A series of new fluorine-containing triazolylpyrimidines and pyrimidinoaminotetrazines results from one-pot reactions of 3,5-diamino-l#-l,2,4-triazole-l-carboximidamide hydrochloride and l,4-diguanidino-2,3,4,5-tetrazine with fluoro-l,3-diketones. Bicyclization of a variety of fluorinated 1,3-diketones gave three fluorinated heterocyclic pyrazolo[l,2,4]triazolo[l,5-a]pyrimidines in moderate yield in a single step.