Hopping of Palladium: Access to Original Polycyclic Structures Containing Three-, Four-, Five- and Six-Membered Rings

摘要

The syntheses of new scaffolds containing small strained rings are described via an original domino reaction. The process works efficiently and selectively via 4-exo-dig/5- or 6-exo-trig/3-exo-trig cyclo-carbopalladations followed by a beta-hydride elimination. During this cascade, the palladium moves several times along the carbon structure for the creation of three new C-C bonds and three new rings.