Diiodine-Mediated Oxidative Reaction for the Construction of Imidazo[1,5-a ]pyridines under Metal-Free Conditions

摘要

An efficient and general protocol has been developed for preparing imidazo[1,5-a]pyridines in moderate to excellent yields by an I2-mediated sequential dual oxidative C(sp(3))-H amination of ethyl pyridin-2-ylacetates with benzylamines. The metal- and peroxide-free reaction involves oxidative dehydrogenation and two C-N couplings.