Synthesis of alpha-arylalkylferrocenes through cesium fluoride-promoted coupling of arylboronic acids with N-tosylhydrazones

摘要

A cesium fluoride-promoted reductive coupling reaction of acylferrocene tosylhydrazones with arylboronic acids has been developed, producing highly substituted -arylalkylferrocenes in moderate to excellent yields. The reaction employs anionic fluorine to facilitate the cleavage of C-B bond. The developed methodology demonstrates a wide substrate scope and high functional groups tolerance. Moreover, the -arylalkylferrocenes compounds were also obtained on a multi-gram scale.