Acid catalyzed aldol condensations of ketones with glyoxylic acid: A simple single-step synthesis of 4-oxo-2,5-heptdienedioic acids

摘要

The acid catalyzed condensations of ketones with glyoxylic acid at 80 degrees C, under neat conditions gives 4-oxo-2,5-heptdienedioic acids in 56-88% yield. The solid state photochemical dimerization of 4-oxo-2,5- heptdienedioic acid under UV light gives 2,7-dioxo-tricyclo[6.2.0.0(3,6)]decane-4,5,9,10-tetracarboxylic acid in 90% yield.