A novel water-soluble fluorescence probe based on ICT lighten for detecting hydrogen sulfide and its application in bioimaging

摘要

Endogenous H2S, considered to be involved inmany physiological processes, has attractedmore attention in fluorescence detection and bioimaging. Therefore, it is necessary to design probes with good biocompatibility and high bioavailability. In this study, a novel fluorescent probe, QN-1, based on azide group and quinoline derivatives was developed for detecting H2S. QN-1 can detect H2S specifically in aqueous phase, which indicated QN-1 has excellentwater solubility. Besides, QN-1 shows excellent properties of higher selectivity and 11-fold fluorescence enhancement at 533 nm. Therefore, QN-1 with excellent properties can be used for cell imaging. (C) 2019 Elsevier B.V. All rights reserved.