A novel near-infrared fluorescent probe for detection of hypobromous acid and its bioimaging applications

摘要

Hypobromous acid (HOBr) is an important reactive oxygen species and has been recently found to be associated with a variety of diseases. However, owing to a lack of effective analytical tools, there is still limited understanding of its roles in living systems. Here, we present a new type of near-infrared fluorescent probe DCSN for HOBr detection. The designed probe exhibits high sensitivity with a low detection limit, excellent selectivity over other interfering species and low cytotoxicity. More interestingly, the fluorescence response behavior of the probe was different from the previous literatures due to the intramolecular charge transfer process. Moreover, we have successfully monitored HOBr in living cells by utilizing DCSN. This probe has potential to be used as a promising tool for better understanding the physiological functions of HOBr. (C) 2019 Elsevier B.V. All rights reserved.