Room Temperature Metal-Free Synthesis of Aryl/Heteroaryl-Substituted Bis(6-aminouracil-5-yl)methanes Using Sulfamic Acid (NH2S03H) as an Efficient and Eco-friendly Organo-Catalyst

摘要

A simple, straightforward and eco-friendly protocol for the synthesis of pharmaceutically-interesting aryl/heteroaryl-substituted bis(6-aminouracil-5-yl)methane derivatives has been developed using sulfamic acid (NH_2SO_3H) as a cost-effective and non-toxic organo-catalyst via pseudo- multicomponent reaction of 6-amino-1,3-dimethyluracil with aromatic/heteroaromatic aldehydes in aqueous ethanol at room temperature. Mild reaction conditions, good to excellent yields, eco- friendliness, easy isolation of products and avoidance of column chromatographic separation are some of the notable features of this protocol.