Effects of raloxifene and alendronate on non-enzymatic collagen cross-links and bone strength in ovariectomized rabbits in sequential treatments after daily human parathyroid hormone (1-34) administration

Kimura S.; Saito M.; Kida Y.; Seki A.; Isaka Y.; Marumo K.

首页> 外文期刊>Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA >Effects of raloxifene and alendronate on non-enzymatic collagen cross-links and bone strength in ovariectomized rabbits in sequential treatments after daily human parathyroid hormone (1-34) administration

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Effects of raloxifene and alendronate on non-enzymatic collagen cross-links and bone strength in ovariectomized rabbits in sequential treatments after daily human parathyroid hormone (1-34) administration

机译：雷洛昔芬及醛酮酸酯对日常人甲状旁腺激素（1-34）给药后顺序处理中卵巢切除兔卵巢切除兔的非酶促胶原交联和骨强度的影响

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This study investigated the effects of raloxifene and alendronate to follow parathyroid hormone (PTH) on bone collagen and biomechanical properties in ovariectomized rabbits. Sequential treatments of raloxifene and alendronate after hPTH(1-34) treatment improved biomechanical properties with and without bone collagen improvement, respectively.

机译：本研究调查了罗昔芬和阿仑膦酸酯的影响跟踪甲醛素激素（PTH）对卵巢切除兔的骨胶原和生物力学性质。 HPTH（1-34）治疗后雷洛昔芬和阿仑膦酸酯的顺序处理分别改善了生物力学性能，分别与骨胶原蛋白改善。

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《Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 》 |2017年第3期| 共11页
作者
Kimura S.; Saito M.; Kida Y.; Seki A.; Isaka Y.; Marumo K.;
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作者单位

Eli Lilly Japan KK Med Sci Med Dev Unit Japan Chuo Ku Sannomiya Plaza Bldg 7-1-5 Isogami Dori;

Jikei Univ Dept Orthopaed Surg Sch Med Minato Ku 3-25-8 Nishi Shimbashi Tokyo 1058461 Japan;

Jikei Univ Dept Orthopaed Surg Sch Med Minato Ku 3-25-8 Nishi Shimbashi Tokyo 1058461 Japan;

Hamri Co Ltd 2638-2 Osaki Koga Ibaraki 3060101 Japan;

Eli Lilly Japan KK Med Sci Med Dev Unit Japan Chuo Ku Sannomiya Plaza Bldg 7-1-5 Isogami Dori;

Jikei Univ Dept Orthopaed Surg Sch Med Minato Ku 3-25-8 Nishi Shimbashi Tokyo 1058461 Japan;

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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学） ;
关键词
Alendronate; Advanced glycation end products; Collagen cross-links; hPTH(1-34); OVX rabbit; Raloxifene;

机译：Alendronate;先进的糖糖末端产品;胶原蛋白交联;HPTH（1-34）;ovx兔子;雷洛昔芬;

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1. Effects of raloxifene and alendronate on non-enzymatic collagen cross-links and bone strength in ovariectomized rabbits in sequential treatments after daily human parathyroid hormone (1-34) administration [J] . Kimura S., Saito M., Kida Y., Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA . 2017 ,第3期

机译：雷洛昔芬及醛酮酸酯对日常人甲状旁腺激素（1-34）给药后顺序处理中卵巢切除兔卵巢切除兔的非酶促胶原交联和骨强度的影响
2. Effect of sequential treatments with alendronate, parathyroid hormone (1-34) and raloxifene on cortical bone mass and strength in ovariectomized rats [J] . Sarah K. Amugongo, Wei Yao, Jurying Jia, Bone . 2014 ,第Null期

机译：阿仑膦酸，甲状旁腺激素（1-34）和雷洛昔芬相继治疗对去卵巢大鼠皮层骨质量和强度的影响
3. Changes in the contents of enzymatic immature, mature, and non-enzymatic senescent cross-links of collagen after once-weekly treatment with human parathyroid hormone (1–34) for 18 months contribute to improvement of bone strength in ovariectomized monkeys [J] . M. Saito, K. Marumo, Y. Kida, Osteoporosis International . 2011 ,第8期

机译：每周一次用人甲状旁腺激素（1-34）治疗18个月后，胶原酶促未成熟，成熟和非酶促衰老交联的含量变化有助于去卵巢猴子的骨强度改善
4. Effect of Sequential Treatments with Alendronate Parathyroid Hormone (1-34) and Raloxifene on Cortical Bone Mass and Strength in Ovariectomized Rats [O] . Sarah K. Amugongo, Wei Yao, Junjing Jia, -1

机译：阿仑膦酸盐甲状旁腺激素（1-34）和雷洛昔芬序贯治疗对去卵巢大鼠皮质骨质量和强度的影响
5. Intermittently Administered Human Parathyroid Hormone(1-34) Treatment Increases Intracortical Bone Turnover and Porosity Without Reducing Bone Strength in the Humerus of Ovariectomized Cynomolgus Monkeys [O] . David B. Burr, Toru Hirano, Charles H. Turner, 2001

机译：间歇地施用的人甲状旁腺激素（1-34）治疗增加了卵巢切除术中肱骨肱骨肱骨肱骨的骨质周转和孔隙率

Effects of raloxifene and alendronate on non-enzymatic collagen cross-links and bone strength in ovariectomized rabbits in sequential treatments after daily human parathyroid hormone (1-34) administration

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