Regio- and Diastereoselective Three-Component Reactions via Trapping of Ammonium Ylides with N-Alkylquinolinium Salts: Synthesis of Multisubstituted Tetra-and Dihydroquinoline Derivatives

摘要

Pd(II)-catalyzed three-component reactions via trapping of ammonium ylides with N-alkylquinoliniurn salts are reported These reactions provided polyfunctional, polycyclic tetrahydroquinolines 4-substituted 1,4 dihydro- quinolines in excellent yields (89-99% and 89-98%, respectively) with high regioselectivities and moderate to good diastereoselectivities (Up to 95:5 dr) under mild reaction conditions.