Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA

Li Hailong; Sun Zhen; Wu Wenting; Wang Xuan; Zhang Mingqiang; Lu Xiaojie; Zhong Wenge; Dai Dongcheng

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Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA

机译：逆电子DIELS- ald反应在DNA上合成哒嗪

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The synthesis of pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels-Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad substrate scope is explored. Functionalized pyridazine products are selected for subsequent DNA-compatible Suzuki Miyaura coupling, acylation, and SNAr substitution reactions, demonstrating the feasibility and versatility of IEDDA reactions for DNA-encoded library synthesis.

机译：基于1,2,5-四嗪的反助剂Diels（IEDDA）反应，开发了DNA对DNA吡啶啶的合成。探索了宽的基板范围。选择官能化的哒嗪产物用于随后的DNA相容的铃木Miyaura偶联，酰化和SNAR取代反应，展示了对DNA编码文库合成的IEDDA反应的可行性和多功能性。

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《Organic letters》 |2018年第22期|共6页
作者
Li Hailong; Sun Zhen; Wu Wenting; Wang Xuan; Zhang Mingqiang; Lu Xiaojie; Zhong Wenge; Dai Dongcheng;
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作者单位

Amgen Res Amgen Asia R&

D Ctr Dept Discovery Modal 4560 Jinke Rd Shanghai 201210 Peoples R China;

Amgen Res Amgen Asia R&

D Ctr Dept Discovery Modal 4560 Jinke Rd Shanghai 201210 Peoples R China;

Amgen Res Amgen Asia R&

D Ctr Dept Discovery Modal 4560 Jinke Rd Shanghai 201210 Peoples R China;

Amgen Res Amgen Asia R&

D Ctr Dept Discovery Modal 4560 Jinke Rd Shanghai 201210 Peoples R China;

Amgen Res Amgen Asia R&

D Ctr Dept Discovery Modal 4560 Jinke Rd Shanghai 201210 Peoples R China;

Chinese Acad Sci Shanghai Inst Mat Med State Key Lab Drug Res 501 Haike Rd Zhang Jiang Hitech Pk Shanghai 200031 Peoples R China;

Amgen Res Amgen Asia R&

D Ctr Dept Discovery Modal 4560 Jinke Rd Shanghai 201210 Peoples R China;

Amgen Res Amgen Asia R&

D Ctr Dept Discovery Modal 4560 Jinke Rd Shanghai 201210 Peoples R China;

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正文语种 eng
中图分类有机化学;
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专利

1. Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA [J] . Li Hailong, Sun Zhen, Wu Wenting, Organic letters . 2018,第22期

机译：逆电子DIELS- ald反应在DNA上合成哒嗪
2. Synthesis of Electron-Deficient 1,3,5-Triazines as Potential Azadienes for Inverse-Electron-Demand Diels-Alder Reactions [J] . Xu GX, Zheng LY, Wang SX, Synthetic Communications . 2010,第1a3期

机译：缺电子的1,3,5-三嗪作为潜在的氮杂二烯，用于反电子需求的Diels-Alder反应
3. NUCLEIC ACID RELATED COMPOUNDS.136.SYNTHESIS OF 2-AMINO-AND 2,6-DIAMINOPURINE DERIVATIVES VIA INVERSE-ELECTRON-DEMAND DIELS-ALDER REACTIONS [J] . Xiaoyu LIN, Morris J.ROBINS Collection of Czechoslovak Chemical Communications . 2006,第7期

机译：核酸相关化合物136.通过反电子需求的Diels-Alder反应合成2-氨基和2,6-二氨基嘌呤衍生物
4. Tandem Diels-Alder Reactions of Arynes: New Method for the Synthesis of Large Poly cyclic Aromatic Compounds and Nanographenes [C] . Diego Pena, Alejandro Criado, Dolores Perez European Symposium on Organic Chemistry . 2009

机译：Arynes的串联Diels-Alder反应：用于合成大聚环芳族化合物和纳米的新方法
5. I. All carbon inverse-electron-demand Diels-Alder reactions: Exploration of the chemistry of an electron-deficient diene. II. Synthesis of some 6,15-disubstituted 2,11-dithia[3.3]metacyclophanes. [D] . Langille, Jonathan D. 2000

机译：I.所有碳反电子需求的Diels-Alder反应：缺电子二烯的化学探索。二。合成一些6,15-二取代的2,11-二硫噻[3.3]甲基环已烷。
6. Application of the Inverse-Electron-Demand Diels-Alder Reaction for Metabolic Glycoengineering [O] . Lisa Maria Haiber, Markus Kufleitner, Valentin Wittmann 2021

机译：代谢糖型逆氧化Diels-ald反应的应用
7. Micro-flow photosynthesis of new dienophiles for inverse-electron-demand Diels-Alder reactions : potential applications for pretargeted in vivo PET imaging [O] . Billaud, E, Shahbazali, E Elnaz, Ahamed, M, 2017

机译：新的亲二烯体的微流光合作用的逆电子需求的Diels-Alder反应：预靶向体内PET成像的潜在应用

Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA

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