Radical Promoted C(sp(2))-S Formation and C(sp(3))-S Bond Cleavage: Access to 2-Substituted Thiochromones

摘要

A radical-promoted cyclization of methylthiolated alkynones with diverse radical precursors has been developed. This strategy occurred via a C(sp(2))-S bond formation and C(sp(3))-S cleavage sequence and allows an efficient synthesis of a variety of phosphoryl-, sulfenyl-, CF2COOEt-, and aryl-containing thiochromone derivatives in moderate to good yields under mild conditions.