Selective Cross-Dehydrogenative C(sp(3))-H Arylation with Arenes

摘要

Selective C(sp(3))-C(sp(2)) bond construction is of central interest in chemical synthesis. Despite the success of classic cross-coupling reactions, the cross-dehydrogenative coupling between inert C(sp(3))-H and C(sp(2))-H bonds represents an attractive alternative toward new C(sp(3))-C(sp(2)) bonds. Herein, we establish a selective inter- and intramolecular C(sp(3))-H arylation of alcohols with nondirected arenes that thereby provides a general pathway to access a wide range of beta-arylated alcohols, including tetrahydronaphthalen-2-ols and benzopyran-3-ols, with high to excellent chemo- and regioselectivity.