Organic-inorganic nanocrystal reductase to promote green asymmetric synthesis

摘要

An acetophenone reductase fromGeotrichum candidum(GcAPRD) was immobilized by the organic-inorganic nanocrystal method. TheGcAPRD nanocrystal presented improved stability and recyclability compared with those of the freeGcAPRD. Moreover, theGcAPRD nanocrystal reduced broad kinds of ketones with excellent enantioselectivities to produce beneficial chiral alcohols such as (S)-1-(3 ',4 '-dichlorophenyl)ethanol with >99% yield and >99% ee. The robust and versatile properties of theGcAPRD nanocrystal demonstrated an approach to promote green asymmetric synthesis and sustainable chemistry.