Cu-catalyzed mild and efficient oxidation of THbCs using air: application in practical total syntheses of perlolyrine and flazin

摘要

A mild, efficient and environmentally benign method for synthesis of aromatic beta-carbolines via Cu(II)-catalyzed oxidation of 1,2,3,4-tetrahydro-beta-carbolines (TH beta Cs) was developed, in which air (O-2) was used as the clean oxidant. This method has advantages such as environmentally friendliness, mildness, very good tolerance of functional groups, high yielding and easy experiment operation. In addition, this new methodology was successfully applied in the efficient and practical total syntheses of beta-carboline alkaloids perlolyrine and flazin.