Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway

摘要

To study the effect and underlying molecular mechanism of eugenol on CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs). The effect of eugenol on the inhibition of immortalized MDSC cell line MSC-2 and murine peritoneal macrophages was detected by MTT. Flow cytometry was used to detect the proapoptosis effect of eugenol on MDSCs. The expression levels of apoptosis-related proteins were detected by western blot. Eugenol has a selective inhibitory effect on MDSCs in a dose-dependent manner, which activates an endogenous apoptosis pathway, leading to apoptosis. Eugenol promotes the apoptosis of MDSCs via the intrinsic pathway.