In Vivo Assessment of Ovarian Tumor Response to Tyrosine Kinase Inhibitor Pazopanib by Using Hyperpolarized C-13-Pyruvate MR Spectroscopy and F-18-FDG PET/CT Imaging in a Mouse Model

摘要

Purpose: To assess in a mouse model whether early or late components of glucose metabolism, exemplified by fluorine 18 (F-18) fluorodeoxyglucose (FDG) positron emission tomography (PET) and hyperpolarized carbon 13 (C-13)-pyruvate magnetic resonance (MR) spectroscopy, can serve as indicators of response in ovarian cancer to multityrosine kinase inhibitor pazopanib.