Transcranial magnetic stimulation modifies astrocytosis, cell density and lipopolysaccharide levels in experimental, autoimmune encephalomyelitis

摘要

Aims: Experimental autoimmune encephalomyelitis (EAE) is considered a valid experimental model for multiple sderosis, a chronic neuroinflammatory condition of the central nervous system. Additionally, some evidence has shown that some microbial products such as the bacterial lipopolysaccharide could lead to the activation reactive immune cells, triggering neuroinflammation. Several studies have found that transcranial magnetic stimulation (TMS) may exert a neuroprotective effect. Therefore, we aimed to assess the effect of TMS on the neuroinflammation occurring in EAE.