Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists

Zloh Mire; Perez-Diaz Noelia; Tang Leslie; Patel Pryank; Mackenzie Louise S.

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Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists

机译：证据表明双氯芬酸和塞洛克西布是甲状腺激素受体β拮抗剂

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Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. Aims: Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen to bind to nuclear receptors.

机译：长期使用NSAIDS与胃肠和心肌梗死等副作用相关联。目的：在Silico方法和药理学中使用，探讨NSAIDs双氯芬酸，Celecoxib和萘普伦与核受体结合的可能性。

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来源
《Life sciences》 |2016年第1期|共7页
作者
Zloh Mire; Perez-Diaz Noelia; Tang Leslie; Patel Pryank; Mackenzie Louise S.;
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作者单位

Univ Hertfordshire Life &

Med Sci Hatfield AL10 9AB Herts England;

Univ Hertfordshire Life &

Med Sci Hatfield AL10 9AB Herts England;

Univ Hertfordshire Life &

Med Sci Hatfield AL10 9AB Herts England;

Univ Hertfordshire Life &

Med Sci Hatfield AL10 9AB Herts England;

Univ Hertfordshire Life &

Med Sci Hatfield AL10 9AB Herts England;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
NSAID; Thyroid hormone; Artery; Toxicology; Triiodothyronine;

机译：NSAID;甲状腺激素;动脉;毒理学;三碘罗酮;

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专利

1. Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists [J] . Zloh Mire, Perez-Diaz Noelia, Tang Leslie, Life sciences . 2016,第1期

机译：证据表明双氯芬酸和塞洛克西布是甲状腺激素受体β拮抗剂
2. Cytoplasm-to-nucleus shuttling of thyroid hormone receptor-beta1 (Trbeta1) is directed from a plasma membrane integrin receptor by thyroid hormone. [J] . Endocrine Research . 2009,第1a2期

机译：甲状腺激素受体β（1 Beta 1）的细胞质至细胞核穿梭是由甲状腺激素从质膜整联蛋白受体引导的。
3. The N-terminal region (A/B) of rat thyroid hormone receptors alpha 1, beta 1, but not beta 2 contains a strong thyroid hormone-dependent transactivation function. [J] . Tomura H, Lazar J, Phyillaier M, Proceedings of the National Academy of Sciences of the United States of America . 1995,第12期

机译：大鼠甲状腺激素受体α1，β1而非β2的N端区域（A / B）具有强大的甲状腺激素依赖性反式激活功能。
4. Generation of the antibody selectively against a novel thyroid hormone receptor beta isoform [C] . Ying Liu, Bei Sun, Yan Ma, The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议）论文集 . 2009

机译：选择性针对新型甲状腺激素受体β亚型的抗体的产生
5. Studies of antagonists and selective agonists of the thyroid hormone receptors. [D] . Yoshihara, Hikari Ananda Infinity. 2003

机译：甲状腺激素受体拮抗剂和选择性激动剂的研究。
6. Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function. [O] . D Forrest, E Hanebuth, R J Smeyne, 1996

机译：缺乏甲状腺激素受体β的小鼠对甲状腺激素的隐性耐药：受体功能的组织特异性调节的证据。
7. Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function. [O] . D. Forrest, E. Hanebuth, R. J. Smeyne, 1996

机译：对缺乏甲状腺激素受体β的小鼠的隐性抵抗缺乏甲状腺激素受体β：受体功能的组织特异性调节的证据。
8. Nuclear Receptors for Thyroid Hormone: Evidence for Nonrandom Distribution Within Chromatin. [R] . Charles, M. A., Ryffel, G. U., Obinata, M., 1975

机译：甲状腺激素的核受体：染色质中非随机分布的证据。

Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists

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