Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats

Ma Chi; Pan Yujun; Yang Zizhen; Meng Zhaojun; Sun Ruohan; Wang Tianyu; Fei Yiping; Fan Wenhui

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Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats

机译：抑制肽的预先施用降低了大鼠中的八蝇多巴胺能神经元的损失

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Aims: In this study, we investigated the effects of Bax-inhibiting peptide (Bip)-V5, an anti-apoptosis membrane-permeable peptide, on the 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) model rats.

机译：目的：在这项研究中，我们研究了抑制肽（BIP）-V5，抗凋亡膜可渗透肽，抗凋亡膜可渗透肽对6-羟基多胺（6-OHDA）诱导的帕金森病（PD）模型大鼠的影响。

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来源
《Life sciences》 |2016年第1期|共8页
作者
Ma Chi; Pan Yujun; Yang Zizhen; Meng Zhaojun; Sun Ruohan; Wang Tianyu; Fei Yiping; Fan Wenhui;
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作者单位

Harbin Med Univ Hosp 1 Dept Neurol Harbin 150001 Heilongjiang Pr Peoples R China;

Harbin Med Univ Hosp 1 Dept Neurol Harbin 150001 Heilongjiang Pr Peoples R China;

Qingdao Cent Hosp Dept Neurol Qingdao 266000 Shandong Peoples R China;

Harbin Med Univ Hosp 4 Dept Ophthalmol Harbin 150001 Heilongjiang Pr Peoples R China;

Harbin Med Univ Hosp 1 Dept Neurol Harbin 150001 Heilongjiang Pr Peoples R China;

Harbin Med Univ Hosp 1 Dept Neurol Harbin 150001 Heilongjiang Pr Peoples R China;

Harbin Med Univ Hosp 1 Dept Neurol Harbin 150001 Heilongjiang Pr Peoples R China;

Harbin Med Univ Hosp 1 Dept Neurol Harbin 150001 Heilongjiang Pr Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Bax-inhibiting peptide; 6-Hydroxydopamine; Dopaminergic neurons; Apoptosis; Parkinson's disease;

机译：抑制肽;6-羟基多胺;多巴胺能神经元;细胞凋亡;帕金森病;

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专利

1. Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats [J] . Ma Chi, Pan Yujun, Yang Zizhen, Life sciences . 2016,第1期

机译：抑制肽的预先施用降低了大鼠中的八蝇多巴胺能神经元的损失
2. Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease. [J] . Harms AS, Barnum CJ, Ruhn KA, Molecular therapy: the journal of the American Society of Gene Therapy . 2011,第1期

机译：在帕金森氏病大鼠模型中，延迟的显性负性TNF基因治疗可阻止黑色素多巴胺能神经元的进行性丧失。
3. Tumor necrosis factor-alpha receptor 1 (p55) knockout only transiently decreases the activation of c-Jun and does not affect the survival of axotomized dopaminergic nigral neurons. [J] . Wessig J, Brecht S, Claussen M, The European Journal of Neuroscience . 2005,第1期

机译：肿瘤坏死因子-α受体1（p55）敲除仅暂时降低c-Jun的激活，并且不影响轴突切除的多巴胺能神经元的存活。
4. Prevention of Calbindin Recruitment into Nigral Dopamine Neurons from MPTP-Induced Degeneration in Macaca fascicularis [C] . Masahiko Takada, Ken-ichi Inoue, Shigehiro Miyachi, Triennial Meeting of the International Basal Ganglia Society . 2009

机译：从Macaca Fascicularis的MPTP诱导的MPTP诱导变性预防Calbindin募集成八氟胺神经元
5. Conditional Loss of Engrailed 1/2 in Rhombic Lip-Derived Neurons Increases Intrinsic Rhythmicity and Decreases Overall Variability of Eupneic Respiration [D] . ?Taylor, Angela P 2020

机译：在菱形唇源性神经元 ENGRAILED 1/2 的条件损耗增加 Eupneic 呼吸的内在节律性，并降低总体变异
6. Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinsons Disease [O] . Ashley S Harms, Christopher J Barnum, Kelly A Ruhn, 2011

机译：延迟显性阴性TNF基因治疗可阻止帕金森氏病大鼠模型中的多巴胺能神经元的逐步丧失
7. Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease [O] . Harms, Ashley S, Barnum, Christopher J, Ruhn, Kelly A, 2011

机译：延迟显性阴性TNF基因治疗可阻止帕金森氏病大鼠模型中的多巴胺能神经元的逐步丧失

Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats

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