Dual targeting of solid lipid nanoparticles grafted with 83-14 MAb and anti-EGF receptor for malignant brain tumor therapy

Kuo Yung-Chih; Lee Chia-Hao

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Dual targeting of solid lipid nanoparticles grafted with 83-14 MAb and anti-EGF receptor for malignant brain tumor therapy

机译：用83-14 mAb和抗EGF受体接枝的固体脂质纳米粒子的双靶向恶性脑肿瘤治疗

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Aims: Solid lipid nanoparticles (SLNs) conjugated with surface 83-14 monoclonal antibody (8314MAb) and anti epithelial growth factor receptor (AEGFR) were synthesized and applied to permeate the blood-brain barrier (BBB) and inhibit the growth of glioblastoma multiforme (GBM).

机译：AIMS：用表面83-14单克隆抗体（8314mAb）和抗上皮生长因子受体（AEGFR）缀合的固体脂质纳米颗粒（SLN），并施加渗透血脑屏障（BBB）并抑制胶质母细胞瘤的生长（ GBM）。

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来源
《Life sciences》 |2016年第1期|共10页
作者
Kuo Yung-Chih; Lee Chia-Hao;
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作者单位

Natl Chung Cheng Univ Dept Chem Engn Chiayi 62102 Taiwan;

Natl Chung Cheng Univ Dept Chem Engn Chiayi 62102 Taiwan;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
83-14 monoclonal antibody; Anti-epithelial growth factor receptor; Blood-brain barrier; Glioblastoma multiforme; Solid lipid nanoparticle; Etoposide;

机译：83-14单克隆抗体;抗上皮生长因子受体;血脑屏障;胶质母细胞瘤多形状;固体脂质纳米粒子;依托泊苷;

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1. Dual targeting of solid lipid nanoparticles grafted with 83-14 MAb and anti-EGF receptor for malignant brain tumor therapy [J] . Kuo Yung-Chih, Lee Chia-Hao Life sciences . 2016,第1期

机译：用83-14 mAb和抗EGF受体接枝的固体脂质纳米粒子的双靶向恶性脑肿瘤治疗
2. Oral delivery of pH-responsive alginate microbeads incorporating folic acid-grafted solid lipid nanoparticles exhibits enhanced targeting effect against colorectal cancer: A dual-targeted approach [J] . International Journal of Biological Macromolecules: Structure, Function and Interactions . 2020,第期

机译：掺入叶酸接枝的固体脂质纳米粒子的pH响应藻酸盐微珠的口服递送表现出对结直肠癌的增强靶向效果：双重针对性的方法
3. Gene therapy of malignant solid tumors by targeting erbB2 receptors and by activating T cells [J] . Cancer biotherapy and radiopharmaceuticals . 2012,第10期

机译：通过靶向erbB2受体和激活T细胞对恶性实体瘤进行基因治疗
4. Perspectives of Boron-Neutron Capture Therapy of Malignant Brain Tumors [C] . V. V. Kanygin, A. I. Kichigin, A. L. Krivoshapkin, International Conference on Physics of Cancer : Interdisciplinary Problems and Clinical Applications . 2017

机译：硼中子捕获治疗恶性脑肿瘤的观点
5. Gold-nanoparticle-based theranostic agents for radiotherapy of malignant solid tumors. [D] . Moeendarbari, Sina. 2016

机译：基于金纳米粒子的治疗剂，用于恶性实体瘤的放射治疗。
6. Gene Therapy of Malignant Solid Tumors by Targeting erbB2 Receptors and by Activating T Cells [O] . Wang-Xiong Hu, He-Ping Chen, Kang Yu, -1

机译：靶向erbB2受体和激活T细胞对恶性实体瘤的基因治疗
7. Molecular target therapy for malignant tumor 3) Molecular target treatment for solid cancer (1) The development to individualization medical treatment which made the EGF receptor of non-small cell lung cancer to be a target. [O] . 2005

机译：用于恶性肿瘤的分子靶疗法3）固体癌的分子靶标处理（1）个性化医疗的发育，使非小细胞肺癌的EGF受体成为靶标。
8. Boron neutron capture therapy of malignant brain tumors at the Brookhaven Medical Research Reactor [R] . Joel, D. D. , Coderre, J. A. , Chanana, A. D. 1996

机译：布鲁克海文医学研究反应堆中的恶性脑肿瘤的硼中子俘获疗法

Dual targeting of solid lipid nanoparticles grafted with 83-14 MAb and anti-EGF receptor for malignant brain tumor therapy

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