IL-27 attenuates the TGF-beta 1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts

Dong Zhaoxing; Zhao Xinxiang; Tai Wenlin; Lei Wen; Wang Yin; Li ZhenKun; Zhang Tao

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IL-27 attenuates the TGF-beta 1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts

机译：IL-27衰减TGF-β1诱导的肺成纤维细胞增殖，分化和胶原合成

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Aims: Pulmonary fibrosis is a type of chronic lung disease and has characteristics that progress quickly, has a high fatality rate and a poor therapeutic effect. Our previous research showed that interleukin/27(IL-27) potentially attenuates BLM-induced pulmonary fibrosis, but the function of IL-27 in lung fibroblasts (LFs) differentiation pulmonary fibrosis is yet to be known.

机译：目的：肺纤维化是一种慢性肺病的类型，具有迅速进展的特征，具有高死亡率和治疗效果差。我们以前的研究表明，白细胞介素/ 27（IL-27）可能会衰减BLM诱导的肺纤维化，但是IL-27在肺成纤维细胞（LFS）分化肺纤维化中的功能尚不知道。

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来源
《Life sciences》 |2016年第1期|共10页
作者
Dong Zhaoxing; Zhao Xinxiang; Tai Wenlin; Lei Wen; Wang Yin; Li ZhenKun; Zhang Tao;
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作者单位

Kunming Med Univ Affiliated Hosp 2 Dept Resp Dianmian Rd 374 Kunming 650101 Yunnan Peoples R;

Kunming Med Univ Affiliated Hosp 2 Dept Radiol Kunming Yunnan Peoples R China;

Kunming Med Univ Affiliated Hosp 2 Dept Clin Lab Yunnan Mol Diagnost Ctr Dianmian Rd Kunming;

Kunming Med Univ Affiliated Hosp 2 Dept Resp Dianmian Rd 374 Kunming 650101 Yunnan Peoples R;

Kunming Med Univ Affiliated Hosp 2 Dept Resp Dianmian Rd 374 Kunming 650101 Yunnan Peoples R;

Kunming Med Univ Affiliated Hosp 2 Dept Resp Dianmian Rd 374 Kunming 650101 Yunnan Peoples R;

Kunming Med Univ Affiliated Hosp 2 Dept Resp Dianmian Rd 374 Kunming 650101 Yunnan Peoples R;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
LFs; TGF-beta 1; Interleukin-27; Proliferation; Differentiation;

机译：LFS;TGF-β1;白细胞介素-27;增殖;分化;

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专利

1. IL-27 attenuates the TGF-beta 1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts [J] . Dong Zhaoxing, Zhao Xinxiang, Tai Wenlin, Life sciences . 2016,第1期

机译：IL-27衰减TGF-β1诱导的肺成纤维细胞增殖，分化和胶原合成
2. AB23A Reduces TGF-beta 1-Induced Human Cardiac Fibroblasts (HCF) Proliferation and Collagen Secretion via MER/ ERK1/2/CREB Pathway [J] . Hu Dinghui, Wu Yanhu, Du Jin, Journal of biomaterials and tissue engineering . 2020,第6期

机译：AB23A通过MER / ERK1 / 2 / CREB途径减少TGF-β1诱导的人心肌成纤维细胞（HCF）增殖和胶原蛋白分泌物
3. Inhibitory effects of oxymatrine on TGF-beta 1-induced proliferation and abnormal differentiation in rat cardiac fibroblasts via the p38MAPK and ERK1/2 signaling pathways [J] . Xu Yini, Xiao Hai, Luo Hong, Molecular medicine reports . 2017,第4aPta3期

机译：通过P38MAPK和ERK1 / 2信号通路对大鼠心肌成纤维细胞中TGF-β1诱导的大鼠心肌成纤维细胞增殖和异常分化的抑制作用
4. STRETCHING-INDUCED COLLAGEN TYPE I SYNTHESIS IN HUMAN TENDON FIBROBLASTS IS MEDIATED BY TGF-beta 1 [C] . Guoguang Yang, Richard C. Crawford, James H-C Wang ASME International Mechanical Engineering Congress and Exposition . 2003

机译：拉伸诱导的胶原型I肌腱成纤维细胞中的合成由TGF-β1介导
5. The effects of enamel matrix derivative on human gingival fibroblasts in vitro study: Proliferation, differentiation and cytokines expression. [D] . Parthasarathy, Kavitha. 2007

机译：牙釉质基质衍生物对人牙龈成纤维细胞的体外研究：增殖，分化和细胞因子表达。
6. Naringenin inhibits transforming growth factor-β1-induced cardiac fibroblast proliferation and collagen synthesis via G0/G1 arrest [O] . Mingxin Liu, Xiping Xu, Jianhua Zhao, -1

机译：柚皮素通过G0 / G1阻滞抑制转化生长因子-β1诱导的心脏成纤维细胞增殖和胶原蛋白合成
7. Maresin 1 inhibits transforming growth factor-β1-induced proliferation, migration and differentiation in human lung fibroblasts [O] . Quanchao Sun, You Wu, Feng Zhao, 2017

机译：Maresin 1抑制人肺成纤维细胞中的增长因子-β1诱导的增殖，迁移和分化

IL-27 attenuates the TGF-beta 1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts

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