Clematichinenoside AR ameliorated spontaneous colitis in Il-10(-/-) mice associated with improving the intestinal barrier function and abnormal immune responses

摘要

Objectives: Clematichinenoside AR (AR) is a saponin extracted for traditional Chinese medicine with the effects of improving the expression of tight junction (TJ) proteins and mediating anti-inflammatory activities. However, its effect on Crohn's disease (CD) is still unknown. We aimed to investigate the impact of AR on CD-like colitis and determine the mechanism underlying its effects.