The administration of Escherichia coli Nissle 1917 ameliorates irinotecan-induced intestinal barrier dysfunction and gut microbial dysbiosis in mice

Wang Yurong; Sun Lie; Chen Shanwen; Guo Shihao; Yue Taohua; Hou Qisheng; Feng Mei; Xu Hao; Liu Yucun; Wang Pengyuan; Pan Yisheng

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The administration of Escherichia coli Nissle 1917 ameliorates irinotecan-induced intestinal barrier dysfunction and gut microbial dysbiosis in mice

机译：大肠杆菌烟头1917的给药改善了小鼠的伊替康诱导的肠道屏障功能障碍和肠道微生物脱泻病

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Aims: The present study investigated the effect of Escherichia coli Nissle 1917 (EcN) on irinotecan-induced intestinal barrier dysfunction and gut microbial dysbiosis in a mouse model and in the human colonic cells lines Caco-2.

机译：目的：本研究调查了大肠杆菌汤（ECN）对小鼠模型和人结肠细胞系Caco-2中的氨管诱导的肠道静脉屏障功能障碍和肠道微生物失调的影响。

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来源
《Life sciences 》 |2019年第2019期| 共10页
作者
Wang Yurong; Sun Lie; Chen Shanwen; Guo Shihao; Yue Taohua; Hou Qisheng; Feng Mei; Xu Hao; Liu Yucun; Wang Pengyuan; Pan Yisheng;
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作者单位

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

Peking Univ Hosp 1 Div Gen Surg 8 Xi ShiKu St Beijing 100034 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生 ;
关键词
Irinotecan; EcN; Chemotherapy; Tight junction; Claudin-1; Gut microbiota;

机译：Irinotecan;ECN;化疗;紧密结;克劳丁-1;肠道微生物;

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1. 枯草芽孢杆菌-灵芝子实体发酵液改善头孢曲松钠诱导的小鼠肠道菌群失调及肠黏膜屏障功能受损 [J] . 刘赫, 范青杰, 刘银辉, 数字中医药（英文） . 2020 ,第003期
2. 枯草芽孢杆菌-灵芝子实体发酵液改善头孢曲松钠诱导的小鼠肠道菌群失调及肠黏膜屏障功能受损 [J] . 刘赫, 范青杰, 刘银辉, 数字中医药(英文) . 2020 ,第003期
3. The administration of Escherichia coli Nissle 1917 ameliorates irinotecan-induced intestinal barrier dysfunction and gut microbial dysbiosis in mice [J] . Wang Yurong, Sun Lie, Chen Shanwen, Life sciences . 2019 ,第期

机译：大肠杆菌烟头1917的给药改善了小鼠的伊替康诱导的肠道屏障功能障碍和肠道微生物脱泻病
4. Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction [J] . Secher, Thomas Frontiers in Immunology . 2017 ,第1期

机译：口服益生菌菌株Nissle 1917减少了对神经炎症的敏感性并修复了实验性自身免疫性脑脊髓炎引起的肠屏障功能障碍
5. Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction [J] . Thomas Secher, Sahar Kassem, Mehdi Benamar, Frontiers in Immunology . 2017 ,第1期

机译：益生菌菌株的口服施用<斜体>大肠杆菌烟头1917降低了对神经炎症和修理实验性自身免疫性脑髓炎诱导的肠道屏障功能障碍的易感性
6. Toxin-Antitoxin Stabilised Biosensors in the Commensal Escherichia coli Nissle 1917 for the Detection of Dysbiotic Changes in the Intestinal Microbiota [C] . T. Ozdemir, A. Fedorec, C. Barnes IET/SynbiCITE Engineering Biology Conference . 2017

机译：用于检测肠道微生物群的非高度大肠杆菌烟头1917中的毒素 - 抗毒素稳定的生物传感器1917
7. Engineered outer membrane vesicles derived from probiotic Escherichia coli Nissle 1917 as recombinant subunit antigen carriers for the development of pathogen-mimetic vaccines [D] . Rosenthal, Joseph A. 2014

机译：源自益生菌大肠杆菌Nissle 1917的工程化外膜囊泡，作为重组亚基抗原载体用于开发病原体模拟疫苗
8. Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction [O] . Thomas Secher, Sahar Kassem, Mehdi Benamar, -1

机译：口服益生菌菌株Nissle 1917降低了对神经炎症的敏感性并修复了实验性自身免疫性脑脊髓炎引起的肠屏障功能障碍
9. Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction [O] . Thomas Secher, Sahar Kassem, Mehdi Benamar, 2017

机译：口服益生菌菌株大肠杆菌Nissle 1917减少对神经炎症的易感性并修复实验性自身免疫性脑脊髓炎引起的肠屏障功能障碍

The administration of Escherichia coli Nissle 1917 ameliorates irinotecan-induced intestinal barrier dysfunction and gut microbial dysbiosis in mice

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