beta-Caryophyllene protects against ischemic stroke by promoting polarization of microglia toward M2 phenotype via the TLR4 pathway

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beta-Caryophyllene protects against ischemic stroke by promoting polarization of microglia toward M2 phenotype via the TLR4 pathway

机译：通过TLR4途径通过TLR4途径促进M2表型的微血花症极化来保护β-亚芳酮保护缺血性卒中

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摘要

Aims: The objective of the study was to determine whether beta-caryophyllene (BCP) exerts a neuroprotective effect in cerebral ischemia-reperfusion (I/R) injury by inhibiting microglial activation and modulating their polarization via the TLR4 pathway.

机译：目的：该研究的目的是通过抑制微胶质激活并通过TLR4途径调节它们的偏振来确定β-亚氰基乙烯（BCP）是否对脑缺血再灌注（I / R）损伤产生神经保护作用。

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《Life sciences》 |2019年第2019期|共13页
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正文语种 eng
中图分类医药、卫生;
关键词
beta-Caryophyllene; Ischemic stroke; Microglia activation; Microglia polarization; TLR4 pathway;

机译：β-羧基;缺血性卒中;小胶质细胞活化;微胶质增长;TLR4途径;

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1. beta-Caryophyllene protects against ischemic stroke by promoting polarization of microglia toward M2 phenotype via the TLR4 pathway [J] . Life sciences . 2019,第期

机译：通过TLR4途径通过TLR4途径促进M2表型的微血花症极化来保护β-亚芳酮保护缺血性卒中
2. MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway [J] . Yang Yongxiang, Ye Yuqin, Kong Chuiguang, Neurochemical research . 2019,第4期

机译：MiR-124通过抑制TLR4途径促进创伤性脑损伤后促进M2的M2偏振和增强的海马神经发生
3. The novel Nrf2 activator CDDO‐EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice [J] . Xia Lei, Hanxia Li, Min Li, CNS neuroscience & therapeutics. . 2021,第1期

机译：新型NRF2活化剂CDDO-EA通过促进小鼠中的M2表型促进小胶质细胞/巨噬细胞极化来衰减脑缺血性损伤
4. MNPs Promote the M2 Subtype towards M1-like Subtype Macrophages and Microglias [C] . Yingze Li, Chang chen, Yu Cheng The 8th International Conference on Magneto- Science（第八届国际磁科学会议）论文集 . -1

机译：Mnps促进M2亚型朝向M1样亚型巨噬细胞和微胶质型
5. An Investigation of Gene Pathways Indicating Neuregulin-1 Immunoregulation Following Ischemic Stroke [D] . Hoque, Dian Mirfat. 2021

机译：缺血性卒中后神经蛋白-1免疫调节基因途径的研究
6. Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization [O] . Mei Jiang, Xinghui Liu, Denghai Zhang, 2018

机译：Celastrol治疗可通过促进IL-33 / ST2轴介导的小胶质细胞/巨噬细胞M2极化来预防急性缺血性中风引起的脑损伤
7. Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization [O] . Mei Jiang, Xinghui Liu, Denghai Zhang, 2018

机译：Celastrol治疗通过促进IL-33 / ST2轴介导的小胶质细胞/巨噬细胞M2极化来保护急性缺血性脑卒中诱导的脑损伤

beta-Caryophyllene protects against ischemic stroke by promoting polarization of microglia toward M2 phenotype via the TLR4 pathway

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