Perturbed ovarian and uterine glucocorticoid receptor signaling accompanies the balanced regulation of mitochondrial function and NF kappa B-mediated inflammation under conditions of hyperandrogenism and insulin resistance

Hu Min; Zhang Yuehui; Guo Xiaozhu; Jia Wenyan; Liu Guoqi; Zhang Jiao; Cui Peng; Li Juan; Li Wei; Wu Xiaoke; Ma Hongxia; Brannstrom Mats; Shao Linus R.; Billig Hakan

首页> 外文期刊>Life sciences >Perturbed ovarian and uterine glucocorticoid receptor signaling accompanies the balanced regulation of mitochondrial function and NF kappa B-mediated inflammation under conditions of hyperandrogenism and insulin resistance

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Perturbed ovarian and uterine glucocorticoid receptor signaling accompanies the balanced regulation of mitochondrial function and NF kappa B-mediated inflammation under conditions of hyperandrogenism and insulin resistance

机译：卵巢癌和子宫糖皮质激素受体信号传导伴随着线粒体功能的平衡调节和NFκB介导的炎症在高衰老和胰岛素抵抗的条件下

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Aim: This study aimed to determine whether glucocorticoid receptor (GR) signaling, mitochondrial function, and local inflammation in the ovary and uterus are intrinsically different in rats with hyperandrogenism and insulin resistance compared to controls.

机译：目的：该研究旨在确定糖皮质激素受体（GR）信号传导（GR）信号传导，线粒体功能和局部炎症是否与对照相比具有高衰变和胰岛素抗性的大鼠本质上不同。

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来源
《Life sciences 》 |2019年第2019期| 共17页
作者
Hu Min; Zhang Yuehui; Guo Xiaozhu; Jia Wenyan; Liu Guoqi; Zhang Jiao; Cui Peng; Li Juan; Li Wei; Wu Xiaoke; Ma Hongxia; Brannstrom Mats; Shao Linus R.; Billig Hakan;
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作者单位

Guangzhou Med Univ Affiliated Hosp 1 Dept Tradit Chinese Med Guangzhou 510120 Guangdong;

Univ Gothenburg Sahlgrenska Acad Inst Neurosci &

Physiol Dept Physiol Endocrinol S-40530;

Heilongjiang Univ Chinese Med Affiliated Hosp 1 Key Lab Dept Obstet &

Gynecol Harbin 150040;

Heilongjiang Univ Chinese Med Affiliated Hosp 1 Key Lab Dept Obstet &

Gynecol Harbin 150040;

Heilongjiang Univ Chinese Med Affiliated Hosp 1 Key Lab Dept Obstet &

Gynecol Harbin 150040;

Heilongjiang Univ Chinese Med Affiliated Hosp 2 Dept Acupuncture &

Moxibust Harbin 150040;

Univ Gothenburg Sahlgrenska Acad Inst Neurosci &

Physiol Dept Physiol Endocrinol S-40530;

Guangzhou Med Univ Affiliated Hosp 1 Dept Tradit Chinese Med Guangzhou 510120 Guangdong;

Heilongjiang Univ Chinese Med Affiliated Hosp 1 Key Lab Dept Obstet &

Gynecol Harbin 150040;

Heilongjiang Univ Chinese Med Affiliated Hosp 1 Key Lab Dept Obstet &

Gynecol Harbin 150040;

Guangzhou Med Univ Affiliated Hosp 1 Dept Tradit Chinese Med Guangzhou 510120 Guangdong;

Univ Gothenburg Sahlgrenska Acad Sahlgrenska Univ Hosp Dept Obstet &

Gynecol S-41345 Gothenburg;

Univ Gothenburg Sahlgrenska Acad Inst Neurosci &

Physiol Dept Physiol Endocrinol S-40530;

Univ Gothenburg Sahlgrenska Acad Inst Neurosci &

Physiol Dept Physiol Endocrinol S-40530;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生 ;
关键词
Glucocorticoid receptor; 11HSD; Mitochondrial malfunction; NF kappa B; Inflammation; Ovary; Uterus; Polycystic ovary syndrome;

机译：糖皮质激素受体;11HSD;线粒体故障;NF Kappa B;炎症;卵巢;子宫;多囊卵巢综合征;

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专利

1. Perturbed ovarian and uterine glucocorticoid receptor signaling accompanies the balanced regulation of mitochondrial function and NF kappa B-mediated inflammation under conditions of hyperandrogenism and insulin resistance [J] . Hu Min, Zhang Yuehui, Guo Xiaozhu, Life sciences . 2019 ,第期

机译：卵巢癌和子宫糖皮质激素受体信号传导伴随着线粒体功能的平衡调节和NFκB介导的炎症在高衰老和胰岛素抵抗的条件下
2. Cannabinoids Delta(9)-tetrahydrocannabinol and cannabidiol may be effective against methamphetamine induced mitochondrial dysfunction and inflammation by modulation of Toll-like type-4(Toll-like 4) receptors and NF-kappa B signaling [J] . Majdi Fatemeh, Taheri Fereshteh, Salehi Pegah, Medical hypotheses . 2019 ,第期

机译：大麻素δ（9） - 通过调节Toll样型-4（Toll样4）受体和NF-Kappa发信号传导可以对甲基苯丙胺诱导的线粒体功能障碍和炎症有效的甲基苯丙胺诱导的线粒体功能障碍和炎症
3. Gymnemic acid alleviates inflammation and insulin resistance via PPAR delta- and NF kappa B-mediated pathways in db/db mice [J] . Li Yumeng, Xiao Yao, Gao Wenge, Food & Function . 2019 ,第9期

机译：通过PPAR DELTA-和NF Kappa B介导的途径在DB / DB小鼠中减轻炎症和胰岛素抗性的炎症和胰岛素抗性
4. Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction [C] . Marni N. Silverman, Esther M. Sternberg International Society for Neuroimmunomodulation . 2012

机译：炎性的糖皮质激素调节及其功能相关性：从HPA轴到糖皮质激素受体功能障碍
5. The Regulation of Cardiac Nrf2 During an Acute Glucose Challenge and the Impact on Mitochondrial Function During Insulin Resistance and Type II Diabetes Mellitus [D] . Thorwald, Max Andrew 2018

机译：急性葡萄糖挑战期间心脏Nrf2的调节及其对胰岛素抵抗和II型糖尿病患者线粒体功能的影响
6. Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling [O] . Louise D. Høeg, Kim A. Sjøberg, Jacob Jeppesen, 2011

机译：脂质诱导的胰岛素抵抗比男性少影响女性并且不伴有炎症或近端胰岛素信号传导受损
7. Perturbed Ovarian and Uterine Glucocorticoid Receptor Signaling Accompanies the Balanced Regulation of Mitochondrial Function and NFkappa;B-Mediated Inflammation under Conditions of Hyperandrogenism and Insulin Resistance [O] . Min Hu, Yuehui Zhang, Xiaozhu Guo, 2019

机译：卵巢和子宫糖皮质激素受体信号传导伴随着线粒体功能的平衡调节和在高衰老和胰岛素抵抗的条件下的线粒体功能和NFκB介导的炎症

Perturbed ovarian and uterine glucocorticoid receptor signaling accompanies the balanced regulation of mitochondrial function and NF kappa B-mediated inflammation under conditions of hyperandrogenism and insulin resistance

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