Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs

Zhuang Shen; Zhong Jia; Bian Yifei; Fan Yingsai; Chen Qiyan; Liu Ping; Liu Zhongjie

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Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs

机译：rhein通过调制NRF2和MAPK来改善脂多糖诱导的肠道阻隔损伤

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摘要

Aims: In this study, we explored the underlying mechanisms of protective effects of rhein against intestinal barrier injury in a rat model, induced by intraperitoneal injection of lipopolysaccharide (LPS).

机译：目的：在这项研究中，我们探讨了Rhein对大鼠模型中肠道阻隔损伤的保护作用的潜在机制，通过腹膜内注射脂多糖（LPS）诱导。

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来源
《Life sciences》 |2019年第2019期|共8页
作者
Zhuang Shen; Zhong Jia; Bian Yifei; Fan Yingsai; Chen Qiyan; Liu Ping; Liu Zhongjie;
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作者单位

China Agr Univ Coll Vet Med Div Tradit Chinese Vet Med Beijing Peoples R China;

China Agr Univ Coll Vet Med Div Tradit Chinese Vet Med Beijing Peoples R China;

China Agr Univ Coll Vet Med Div Tradit Chinese Vet Med Beijing Peoples R China;

China Agr Univ Coll Vet Med Div Tradit Chinese Vet Med Beijing Peoples R China;

China Agr Univ Coll Vet Med Div Tradit Chinese Vet Med Beijing Peoples R China;

China Agr Univ Coll Vet Med Div Tradit Chinese Vet Med Beijing Peoples R China;

China Agr Univ Coll Vet Med Div Tradit Chinese Vet Med Beijing Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Rhein; LPS; Intestinal barrier injury; Oxidative stress; Inflammation; MAPKs; Nrf2;

机译：莱茵;LPS;肠道势损伤;氧化应激;炎症;MAPKS;NRF2;

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专利

1. Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs [J] . Zhuang Shen, Zhong Jia, Bian Yifei, Life sciences . 2019,第期

机译：rhein通过调制NRF2和MAPK来改善脂多糖诱导的肠道阻隔损伤
2. Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-kappa B/MLCK and Nrf2 Signaling Pathways [J] . Yuan Jinwen, Che Siyan, Zhang Li, Journal of Agricultural and Food Chemistry . 2021,第14期

机译：通过MAPK / NF-κB/ mLCK和NRF2信号传导途径黄酮类胰蛋白酶对乙醇诱导的肠道阻隔损伤的重复影响
3. Preventive Effects of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK/Nrf2 Pathways [J] . Jui-Shu Chang, Hung-Jen Lin, Jeng-Shyan Deng, Evidence-based complementary and alternative medicine: eCAM . 2018,第7期

机译：鹿茸通过抑制MAPK /NF-κB活化并诱导AMPK / Nrf2途径对脂多糖诱导的小鼠急性肺损伤的预防作用
4. Acrermonium terricola culture plays anti-inflammatory and antioxidant roles upon modulating MAPK signaling pathways in rats with lipopolysaccharide-induced mastitis [C] . Shuang Zhou, Jian Zheng, Enyue Yao, The 6th International Symposium on Dairy Cow Nutrition and Milk Quality（第六届“奶牛营养与牛奶质量”国际研讨会）论文集 . -1

机译：Acrmonium Terricola培养物在调节脂多糖诱导的乳腺炎大鼠的MAPK信号通路时发挥抗炎和抗氧化作用
5. Interleukin -1beta (IL-1β) modulation of intestinal epithelial tight junction barrier [D] . Al-Sadi, Rana M. 2007

机译：白细胞介素-1β（IL-1β）对肠上皮紧密连接屏障的调节
6. Preventive Effects of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK/Nrf2 Pathways [O] . Jui-Shu Chang, Hung-Jen Lin, Jeng-Shyan Deng, 2018

机译：鹿茸通过抑制MAPK /NF-κB活化并诱导AMPK / Nrf2途径对脂多糖诱导的小鼠急性肺损伤的预防作用
7. Rhein inhibits lipopolysaccharide-induced intestinal injury during sepsis by blocking the toll-like receptor 4 nuclear factor-κB pathway [O] . KE ZHANG, XIAN FA JIAO, JIN XIU LI, 2015

机译：通过阻断Toll样受体4核因子-κB途径，rhein抑制败血症期间血液多糖诱导的肠损伤

Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs

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