Znhit1 inhibits breast cancer by up-regulating PTEN to deactivate the PI3K/ Akt/mTOR pathway

Cui Chunguo; Li Sijie; Wu Di

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Znhit1 inhibits breast cancer by up-regulating PTEN to deactivate the PI3K/ Akt/mTOR pathway

机译：通过升压PTEN来抑制乳腺癌，以取消激活PI3K / AKT / MTOR途径

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Aims: Breast cancer (BC) is the most frequently diagnosed cancer, ranking sixth as the cause of death among females in China. Zinc finger HIT-type containing 1 (Znhit1) is a pivotal factor for inhibition of gene mutation and cell proliferation. Due to the unknown function of Znhit1 in cancers, we aimed to explore the role of Znhit1 in BC as well as the underlying mechanisms.

机译：目的：乳腺癌（BC）是最常见的癌症，排名第六是中国女性死亡的原因。含有1（ZnHit1）的锌指击型是用于抑制基因突变和细胞增殖的枢转因子。由于Znhit1在癌症中的未知功能，我们旨在探讨Znhit1在BC以及潜在机制的作用。

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来源
《Life sciences》 |2019年第2019期|共8页
作者
Cui Chunguo; Li Sijie; Wu Di;
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作者单位

Jilin Univ China Japan Union Hosp Dept Breast Surg Changchun 130031 Jilin Peoples R China;

Jilin Univ Hosp 1 Dept Breast Surg 71 Xinmin St Changchun 130021 Jilin Peoples R China;

Jilin Univ Hosp 1 Dept Breast Surg 71 Xinmin St Changchun 130021 Jilin Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Breast cancer; Znhit1; PTEN; PI3K/Akt/mTOR; Prognosis;

机译：乳腺癌;Znhit1;PTEN;PI3K / AKT / MTOR;预后;

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专利

1. Znhit1 inhibits breast cancer by up-regulating PTEN to deactivate the PI3K/ Akt/mTOR pathway [J] . Cui Chunguo, Li Sijie, Wu Di Life sciences . 2019,第期

机译：通过升压PTEN来抑制乳腺癌，以取消激活PI3K / AKT / MTOR途径
2. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway [J] . Guo Yan, Chang Hui, Li Jing, Apoptosis: An international journal on programmed cell death . 2015,第8期

机译：胸腺素α1通过PTEN介导的PI3K / Akt / mTOR信号通路抑制作用抑制乳腺癌细胞的增殖并诱导其凋亡
3. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells [J] . Hong-Wei Zhang, Jin-Jiao Hu, Ruo-Qiu Fu, Scientific reports. . 2018,第1期

机译：类黄酮通过下调PI3Kγ介导的PI3K / AKT / mTOR / p70S6K / ULK信号通路抑制人乳腺癌细胞的增殖并诱导细胞凋亡和自噬
4. Label-free phosphoproteomics method to investigate signaling pathways downstream of novel PI3K/mTOR inhibitors in cancer cells [C] . Pedro Casado, Juan Carlos Rodriguez-Prados, Sabina Cosulich, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：无标记的磷蛋白质方法，用于研究新型PI3K / MTOR抑制剂在癌细胞中的信号通路
5. Sensitivity of MCF-7 breast cancer cells to anticancer drugs is decreased by activation of the PI3K/PDK/Akt signal transduction pathway. [D] . Navolanic, Patrick M. 2004

机译：通过激活PI3K / PDK / Akt信号转导途径，MCF-7乳腺癌细胞对抗癌药物的敏感性降低。
6. Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention [O] . Nicole M. Davis, Melissa Sokolosky, Kristin Stadelman, 2014

机译：乳腺癌中EGFR / PI3K / PTEN / Akt / mTORC1通路的失控：治疗干预的可能性
7. Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention [O] . Davis, Nicole M., Sokolosky, Melissa, Stadelman, Kristin, 2014

机译：乳腺癌中EGFR / PI3K / PTEN / Akt / mTORC1通路的失控：治疗干预的可能性

Znhit1 inhibits breast cancer by up-regulating PTEN to deactivate the PI3K/ Akt/mTOR pathway

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