Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice

Zhang Jing; Cao Peng; Gui Jingjing; Wang Xin; Han Jun; Wang Yuwei; Wang Guodong

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Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice

机译：芳替苯胺改善肾损伤并抑制糖尿病DB / DB小鼠的内质网胁迫

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Aims: Diabetic nephropathy (DN) is the most common complication of diabetes mellitus. Endoplasmic reticulum (ER) plays an important role in the development and progression of DN. Arctigenin (ATG), a lignan extract from Fructus Arctii, exhibits anti-inflammatory, anticarcinogenic, anti-oxidative stress and immunomodulatory properties. The present research aimed to investigate whether ATG could protect against diabetes-related renal injury and inhibit ER stress in db/db mice.

机译：目的：糖尿病肾病（DN）是糖尿病最常见的并发症。内质网（ER）在DN的发展和进展中起着重要作用。来自Fructus Arctii的芳替苯胺（ATG），具有抗炎，抗诱导性，抗氧化应激和免疫调节性能。目前的研究旨在调查ATG是否可以防止糖尿病相关的肾损伤并抑制DB / DB小鼠中的ER应激。

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来源
《Life sciences》 |2019年第2019期|共8页
作者
Zhang Jing; Cao Peng; Gui Jingjing; Wang Xin; Han Jun; Wang Yuwei; Wang Guodong;
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作者单位

Wannan Med Coll Affiliated Hosp 1 Dept Nephrol Yijishan Hosp Wuhu 241001 Peoples R China;

Wannan Med Coll Affiliated Hosp 1 Dept Nephrol Yijishan Hosp Wuhu 241001 Peoples R China;

Wannan Med Coll Affiliated Hosp 1 Dept Nephrol Yijishan Hosp Wuhu 241001 Peoples R China;

Wannan Med Coll Affiliated Hosp 1 Dept Nephrol Yijishan Hosp Wuhu 241001 Peoples R China;

Wannan Med Coll Anhui Prov Engn Res Ctr Polysaccharide Drugs Anhui Prov Key Lab Act Biol Macromol;

Wannan Med Coll Affiliated Hosp 1 Dept Nephrol Yijishan Hosp Wuhu 241001 Peoples R China;

Wannan Med Coll Anhui Prov Engn Res Ctr Polysaccharide Drugs Anhui Prov Key Lab Act Biol Macromol;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Arctigenin; Diabetic nephropathy; ER stress; Apoptosis;

机译：芳脂素;糖尿病肾病;ER应激;细胞凋亡;

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专利

1. Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice [J] . Zhang Jing, Cao Peng, Gui Jingjing, Life sciences . 2019,第期

机译：芳替苯胺改善肾损伤并抑制糖尿病DB / DB小鼠的内质网胁迫
2. Micheliolide ameliorates diabetic kidney disease by inhibiting Mtdh-mediated renal inflammation in type 2 diabetic db/db mice [J] . Liu Wenting, Chen Xiaowen, Wang Yuxian, Pharmacological research: The official journal of The Italian Pharmacological Society . 2019,第期

机译：通过抑制2型糖尿病DB / dB小鼠的MTDH介导的肾炎，Micheliolide改善了糖尿病肾疾病
3. Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice [J] . Ghosh, S., Khazaei, American Journal of Physiology . 2009,第4aPta2期

机译：适度的运动衰减Caspase-3活性，氧化应激，并抑制DB / DB小鼠中糖尿病肾病的进展
4. Effects of Radix Total Glucosides of Paeonia on the Endoplasmic Reticulum Stress and Macrophage Recruitment on Diabetic Cardiomyopathy Rats [C] . Hongyu Kang, Ximin Liu, Yaping Zheng, International Conference on Materials Engineering and Information Technology Applications . 2017

机译：芍药的含量对糖尿病心肌病大鼠内质网胁迫和巨噬细胞募集的影响
5. Potential role of endoplasmic reticulum redox changes in endoplasmic reticulum stress and impaired protein folding in obesity-associated insulin resistance [D] . Sarkar, Deboleena 2013

机译：内质网氧化还原变化在内质网应激和蛋白质折叠受损在肥胖相关胰岛素抵抗中的潜在作用
6. Moderate exercise attenuates caspase-3 activity oxidative stress and inhibits progression of diabetic renal disease in db/db mice [O] . S. Ghosh, M. Khazaei, F. Moien-Afshari, -1

机译：适度运动会减弱db / db小鼠的caspase-3活性氧化应激并抑制糖尿病性肾脏疾病的进展
7. Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice [O] . Ghosh, S., Khazaei, M., Moien-Afshari, F., 2009

机译：适度运动会减弱db / db小鼠的caspase-3活性，氧化应激并抑制糖尿病性肾脏疾病的进展

Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice

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