Linc00152 knockdown inactivates the Akt/mTOR and Notch1 pathways to exert its anti-hemangioma effect

Wang Yanlin; Li Miaomiao; Dong Changxian; Ma Yuchun; Xiao Li; Zuo Song; Gong Yubin; Ren Tengfei; Sun Bin

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Linc00152 knockdown inactivates the Akt/mTOR and Notch1 pathways to exert its anti-hemangioma effect

机译：LINC00152敲除灭活AKT / MTOR和Notch1途径，以发挥其抗血管瘤效应

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Aims: Infantile hemangioma (IH) is one of the most common benign vascular tumors occurred in infants. Linc00152 is a kind of long non-coding RNAs (lncRNAs) and acts as a tumor oncogene. Recent study reported that Linc00152 is highly expressed in clinical IH tissues. However, the exact biological roles have not yet been investigated. The aim of the present study was to investigate the oncogenic roles of Linc00152 in IH and the underlying mechanism in vitro.

机译：目的：婴儿血管瘤（IH）是婴儿最常见的良性血管肿瘤之一。 LINC00152是一种长期非编码RNA（LNCRNA），并充当肿瘤癌基因。最近的研究报告说，LINC00152在临床IH组织中高度表达。但是，尚未调查确切的生物角色。本研究的目的是探讨LINC00152在IH和体外潜在机制的致癌作用。

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来源
《Life sciences 》 |2019年第2019期| 共7页
作者
Wang Yanlin; Li Miaomiao; Dong Changxian; Ma Yuchun; Xiao Li; Zuo Song; Gong Yubin; Ren Tengfei; Sun Bin;
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作者单位

Henan Prov Peoples Hosp Dept Hemangioma &

Vasc Malformat 7 Weiwu Rd Zhengzhou 450003 Henan;

Henan Prov Peoples Hosp Dept Hemangioma &

Vasc Malformat 7 Weiwu Rd Zhengzhou 450003 Henan;

Henan Prov Peoples Hosp Dept Hemangioma &

Vasc Malformat 7 Weiwu Rd Zhengzhou 450003 Henan;

Henan Prov Peoples Hosp Dept Hemangioma &

Vasc Malformat 7 Weiwu Rd Zhengzhou 450003 Henan;

Henan Prov Peoples Hosp Dept Hemangioma &

Vasc Malformat 7 Weiwu Rd Zhengzhou 450003 Henan;

Henan Prov Peoples Hosp Dept Hemangioma &

Vasc Malformat 7 Weiwu Rd Zhengzhou 450003 Henan;

Henan Prov Peoples Hosp Dept Hemangioma &

Vasc Malformat 7 Weiwu Rd Zhengzhou 450003 Henan;

Henan Prov Peoples Hosp Dept Hemangioma &

Vasc Malformat 7 Weiwu Rd Zhengzhou 450003 Henan;

Henan Prov Peoples Hosp Dept Hemangioma &

Vasc Malformat 7 Weiwu Rd Zhengzhou 450003 Henan;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生 ;
关键词
Infantile hemangioma; Long non-coding RNAs; Hemangioma-derived endothelial cells; Linc00152; Akt/mTOR; Notch1;

机译：婴儿血管瘤;长期非编码RNA;血管瘤衍生的内皮细胞;LINC00152;akt / mtor;notch1;

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专利

1. Linc00152 knockdown inactivates the Akt/mTOR and Notch1 pathways to exert its anti-hemangioma effect [J] . Wang Yanlin, Li Miaomiao, Dong Changxian, Life sciences . 2019 ,第期

机译：LINC00152敲除灭活AKT / MTOR和Notch1途径，以发挥其抗血管瘤效应
2. lncRNA LINC00152 knockdown had effects to suppress biological activity of lung cancer via EGFR/PI3K/AKT pathway [J] . Yan Zhang, Cheng Xiang, Yuling Wang, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2017 ,第期

机译：LNCRNA LINC00152敲低的效果抑制肺癌的生物活性通过EGFR / PI3K / AKT途径
3. Knockdown of inhibitor of differentiation 1 suppresses proliferation and induces apoptosis by inactivating PI3K/Akt/mTOR signaling in hemangioma-derived endothelial cells [J] . Sun Bin, Dong Changxian, Lei Hongzhao, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2019 ,第期

机译：分化抑制剂1抑制抑制增殖并通过在血管瘤衍生的内皮细胞中灭活PI3K / AKT / mT信号传导来诱导细胞凋亡
4. Quantitative Analysis of AKT/mTOR Pathway using Multiplex-Immunoprecipitation and Targeted Mass Spectrometry [C] . Bhavin Patel, Alex Behling, Leigh Foster, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：多重免疫沉淀和靶向质谱法的定量分析AKT / mTOR途径
5. Dual Modulator of the Akt and JNK Pathways Targets mTOR in Human Adenocarcinoma Cells [D] . Curless, Blair P. 2018

机译：Akt和JNK途径的双重调节剂靶向人类腺癌细胞中的mTOR
6. Knockdown of lncRNA XIST suppresses osteosarcoma progression by inactivating AKT/mTOR signaling pathway by sponging miR-375-3p [O] . Xin Sun, Bo Wei, Zhi-Heng Peng, 2019

机译：敲低lncRNA XIST可通过使miR-375-3p失活而使AKT / mTOR信号通路失活而抑制骨肉瘤的进展
7. Osteopontin Knockdown Inhibits αv,β3 Integrin-Induced Cell Migration and Invasion and Promotes Apoptosis of Breast Cancer Cells by Inducing Autophagy and Inactivating the PI3K/Akt/mTOR Pathway [O] . Hao Zhang, Man Guo, Jin-hong Chen, 2014

机译：骨桥蛋白抑制抑制αv，β3整合素诱导的细胞迁移和侵袭，并通过诱导自噬和灭活pI3K / akt / mTOR途径促进乳腺癌细胞的凋亡

Linc00152 knockdown inactivates the Akt/mTOR and Notch1 pathways to exert its anti-hemangioma effect

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