Synthesis of 1 '-tetrazolylmethyl-spiro[pyrrolidine-3,3 '-oxindoles] via two coupled one-pot processes Ugi-azide/Pictet-Spengler and oxidative spiro-rearrangement

摘要

Six novel tris-heterocycles 1'-tetrazolylmethyl-spiro[pyrrolidine-3,3'-oxindoles] were synthesized in 39-82% yields in two experimental steps: (i) a one-pot Ugi-azide/Pictet-Spengler process coupled to (ii) a one-pot oxidative spiro-rearrangement. The synthesized polyheterocycles could be used for further in vitro studies because they contain moieties present in various anticancer bioactive molecules and drugs.