Molecular recognition of methamphetamine by carboxylatopillar[5]arene: drug-dependent complexation stoichiometry and insights into medical applications

摘要

The molecular recognition of the carboxylatopillar[5]arene on methamphetamine showed interconversion between H-2:G reversible arrow H:G stoichiometries with dependence on drug concentration. The study simulated conditions of severe metabolic acidosis (pH 7.00) and presented intelligent and promising dynamics for the removal of overdosed drugs or poisons in the circulatory system.