Mastering bioactive coatings of metal oxide nanoparticles and surfaces through phosphonate dendrons

摘要

We reported herein an efficient method for constructing dendritic bisphosphonic acid tweezers of generation 1 and 2, which have been proven as versatile surface coatings for metal oxides implants or nanoparticles. These dendritic structures were successfully utilized for different purposes: (i) biocompatible coverings for iron oxide nanoparticles through in vitro assays, (ii) antifouling surface coatings for silica through quartz crystal microbalance studies, and (iii) stabilizing ligands for magnetic nanoparticle-microbubble conjugates via preliminary Langmuir monolayer studies.