Increased abundance of myeloid-derived suppressor cells and Th17 cells in peripheral blood of newly-diagnosed Parkinson's disease patients

摘要

Parkinson's disease (PD) is a neurodegenerative disease that is often associated with corresponding neuroinflammation. In the present study, flow cytometry was used to detect T-helper 17 (Th17) cells and myeloid-derived suppressor cells (MDSCs) in 18 patients newly diagnosed with PD as well as 18 normal controls. Results showed that Th17 cells and MDSCs were significantly higher in peripheral blood of PD patients compared to controls (P < 0.001). Furthermore, there was no correlation between Th17 cells and MDSCs in peripheral blood of PD patients. Our findings suggest that Th17 cells and MDSCs may be important factors related to the occurrence and progression of PD, as well as the development of PD-related neuroinflammation. (C) 2017 Elsevier B.V. All rights reserved.