Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses

Han Shuguang; Du Zhengde; Liu Ke; Gong Shusheng

首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses

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Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses

机译：尼古酰胺核苷通过回收头发细胞带状突触来保护噪声引起的听力损失

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Objective: Nicotinamide riboside (NR) has been proved to protect the hearing. To achieve animal models of temporary threshold shift (TTS) and permanent threshold shift (PTS) respectively, evaluate the dynamic change of ribbon synapse before and after NR administration.

机译：目的：硝基酰胺核苷（NR）已被证明是保护听力。为了实现临时阈值移位（TTS）和永久阈值移位（PTS）的动物模型，评估NR管理前后带突触的动态变化。

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《Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences》 |2020年第1期|共9页
作者
Han Shuguang; Du Zhengde; Liu Ke; Gong Shusheng;
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作者单位

Capital Med Univ Beijing Friendship Hosp Dept Otolaryngol Head &

Neck Surg 95th Yongan Rd;

Capital Med Univ Beijing Friendship Hosp Dept Otolaryngol Head &

Neck Surg 95th Yongan Rd;

Capital Med Univ Beijing Friendship Hosp Dept Otolaryngol Head &

Neck Surg 95th Yongan Rd;

Capital Med Univ Beijing Friendship Hosp Dept Otolaryngol Head &

Neck Surg 95th Yongan Rd;

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原文格式 PDF
正文语种 eng
中图分类人体生理学;
关键词
Hidden hearing loss; Noise; Cochlea; Ribbon synapse; Nicotinamide ribose; Oxidative damage;

机译：隐藏的听力损失;噪音;耳蜗;丝带突触;烟酰胺核糖;氧化损伤;

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1. Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses [J] . Han Shuguang, Du Zhengde, Liu Ke, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2020,第1期

机译：尼古酰胺核苷通过回收头发细胞带状突触来保护噪声引起的听力损失
2. Lack of brain-derived neurotrophic factor hampers inner hair cell synapse physiology, but protects against noise-induced hearing loss [J] . ZuccottiA., KuhnS., JohnsonS.L., The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2012,第25期

机译：缺乏脑源性神经营养因子会阻碍内部毛细胞突触生理，但可防止噪声引起的听力损失
3. Functional alteration of ribbon synapses in inner hair cells by noise exposure causing hidden hearing loss [J] . Liu Huihui, Lu Jiawen, Wang Zhongying, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2019,第期

机译：噪声暴露导致隐藏听力损失的内毛细胞中带状突触的功能改变
4. Cochlea Hair Cell Rescue after a Noise-Induced Hearing Loss using a Low Level Laser Therapy (LLLT) [C] . Chung-Ku Rhee, Chan Woong Bank, Jae Yun Jung, Photonic therapeutics and diagnostics VII . 2011

机译：使用低水平激光疗法（LLLT）导致噪声引起的听力损失后，耳蜗毛细胞的抢救
5. Drug Repurposing of an EGFR Inhibitor for Protection against Noise-Induced Hearing Loss [D] . Dabestani, Parinaz Jila. 2020

机译：抗噪声诱导损失保护EGFR抑制剂的药物修复
6. Activation of SIRT3 by the NAD+ precursor nicotinamide riboside protects from noise-induced hearing loss [O] . Kevin D. Brown, Sadia Maqsood, Jing-Yi Huang, -1

机译：NAD +前体烟酰胺核糖苷对SIRT3的激活可防止噪音引起的听力损失
7. Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss [O] . Brown Kevin D., Maqsood Sadia, Huang Jing-Yi, 2014

机译：NAD +前体烟酰胺核糖苷对SIRT3的激活可防止噪音引起的听力损失

Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses

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