Coaxiality of Foxb1- and parvalbumin-expressing neurons in the lateral hypothalamic PV1-nucleus

摘要

In the ventrolateral hypothalamus, the PV1 -nucleus is defined by its population of parvalbumin-expressing neurons. During embryogenesis, the ventrolateral hypothalamus is colonized also by Foxb1-expressing neurons. In adult Foxb1-EGFP mice, many immunofluorescent neurons were found within the region that is occupied by the PV1-nucleus. They formed a cloud around the axial cord of the parvalbumin-immunopositive cells, which they greatly outnumber (3:1). Only a small proportion of the neurons in the PV1-nucleus co-expressed both parvalbumin and Foxbl. In the light of these findings, a redesignation of this lateral hypothalamic structure as the PV1-Foxbl nucleus would more accurately reflect its specific biochemical properties.