Sitagliptin protects the cognition function of the Alzheimer's disease mice through activating glucagon-like peptide-1 and BDNF-TrkB signalings

Dong Qing; Teng Shuai-Wen; Wang Yue; Qin Feng; Li Yue; Ai Lu-Lu; Yu Hui

首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Sitagliptin protects the cognition function of the Alzheimer's disease mice through activating glucagon-like peptide-1 and BDNF-TrkB signalings

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Sitagliptin protects the cognition function of the Alzheimer's disease mice through activating glucagon-like peptide-1 and BDNF-TrkB signalings

机译：SitaGliptin通过激活胰高血糖素肽-1和BDNF-TRKB信号来保护阿尔茨海默病小鼠的认知功能

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Bacicground: Sitagliptin is an anti-diabetic drug and its effects on Alzheimer's disease (AD) remain controversial. This study aimed to investigate the protective effect of sitagliptin on the cognition in AD and its underlying molecular mechanism.

机译：Bacicground：SitaGliptin是一种抗糖尿病药物，其对阿尔茨海默病（AD）的影响仍然存在争议。本研究旨在探讨SITAGLIPTIN对AD及其潜在分子机制认知的保护作用及其潜在的分子机制。

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来源
《Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences》 |2019年第2019期|共7页
作者
Dong Qing; Teng Shuai-Wen; Wang Yue; Qin Feng; Li Yue; Ai Lu-Lu; Yu Hui;
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作者单位

Sun Yat Sen Univ Affiliated Hosp 3 Dept Neurol 600 Tianhe Rd Guangzhou 510630 Guangdong;

Shandong Univ Sch Basic Med Dept Cell &

Neurobiol Shandong Prov Key Lab Mental Disorders 44;

Shandong Univ Sch Basic Med Dept Cell &

Neurobiol Shandong Prov Key Lab Mental Disorders 44;

Sun Yat Sen Univ Affiliated Hosp 3 Dept Neurosurg Guangzhou 510630 Guangdong Peoples R China;

Sun Yat Sen Univ Affiliated Hosp 3 Dept Tradit Chinese Med Guangzhou 510630 Guangdong Peoples;

Sun Yat Sen Univ Affiliated Hosp 3 Dept Neurol 600 Tianhe Rd Guangzhou 510630 Guangdong;

Shandong Univ Sch Basic Med Dept Cell &

Neurobiol Shandong Prov Key Lab Mental Disorders 44;

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原文格式 PDF
正文语种 eng
中图分类人体生理学;
关键词
Sitagliptin; Alzheimer's disease; Cognitive function; Synaptic plasticity; TrkB signaling;

机译：SitaGliptin;阿尔茨海默病;认知功能;突触塑性;TRKB信号传导;
入库时间 2022-08-19 17:34:05

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1. Sitagliptin protects the cognition function of the Alzheimer's disease mice through activating glucagon-like peptide-1 and BDNF-TrkB signalings [J] . Dong Qing, Teng Shuai-Wen, Wang Yue, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2019,第期

机译：SitaGliptin通过激活胰高血糖素肽-1和BDNF-TRKB信号来保护阿尔茨海默病小鼠的认知功能
2. Bone marrow mesenchymal stem cells-derived exosomes reduce A beta deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway [J] . Wang Xinhui, Yang Guojie Cell biology international. . 2021,第4期

机译：骨髓间充质干细胞衍生的外泌体通过激活鞘氨酸激酶/鞘氨酸-1-磷酸四磷信号通路，降低β沉积并通过Alzheimer疾病提高小鼠的认知功能回收
3. In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model [J] . VargasJ.Y., FuenzalidaM., InestrosaN.C. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2014,第6期

机译：Wnt信号通路的体内激活增强了成年小鼠的认知功能并逆转了阿尔茨海默病模型中的认知缺陷
4. Conformational Dynamics of Large "Two-Headed Ligand Keys": Unlocking the Glucagon-Like Peptide-1 Receptor Signaling Pathway [C] . Graham M. West, Kyle W. Sloop, Francis S. Willard, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：大“双头配体键”的构象动态：解锁胰高血糖素样肽-1受体信号传导路径
5. Backbone modification of glucagon-like peptide-1 (GLP-1) to alter signaling at the GLP-1 receptor. [D] . Hager, Marlies Veronica. 2017

机译：胰高血糖素样肽1（GLP-1）的骨干修饰，以改变GLP-1受体处的信号传导。
6. Electroacupuncture Protects Cognition by Regulating Tau Phosphorylation and Glucose Metabolism via the AKT/GSK3β Signaling Pathway in Alzheimer’s Disease Model Mice [O] . Anping Xu, Qingtao Zeng, Yinshan Tang, 2020

机译：通过在阿尔茨海默病模型小鼠中通过AKT /GSK3β信号通路调节Tau磷酸化和葡萄糖代谢来保护认知。
7. In vivo Activation of Wnt Signaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model [O] . J. Y. Vargas, M. Fuenzalida, N. C. Inestrosa 2014

机译：在VIVO激活WNT信号通路增强成人小鼠的认知功能，并在阿尔茨海默病模型中逆转认知缺陷

Sitagliptin protects the cognition function of the Alzheimer's disease mice through activating glucagon-like peptide-1 and BDNF-TrkB signalings

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