Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization.

Shuttleworth SJ; Connors RV; Fu J; Liu J; Lizarzaburu ME; Qiu W; Sharma R; Wanska M; Zhang AJ

首页> 外文期刊>Current medicinal chemistry >Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization.

【24h】

Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization.

机译：设计和合成以蛋白质超家族为目标的化学文库，用于铅的鉴定和优化。

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

This review chronicles original literature dating back to 1992 outlining the applications of parallel synthesis and combinatorial chemistry to the synthesis of compound libraries focused towards specific superfamilies of molecular targets. Target families that have received significant literature coverage include kinases, proteases, nuclear hormone receptors and cell surface receptors, notably GPCRs.

机译：这篇评论记录了可追溯至1992年的原始文献，概述了平行合成和组合化学在化合物库合成中的应用，这些化合物库主要针对分子靶标的超家族。已有大量文献报道的靶标家族包括激酶，蛋白酶，核激素受体和细胞表面受体，特别是GPCR。

著录项

来源
《Current medicinal chemistry》 |2005年第11期|共43页
作者
Shuttleworth SJ; Connors RV; Fu J; Liu J; Lizarzaburu ME; Qiu W; Sharma R; Wanska M; Zhang AJ;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Drug Design; Drug Evaluation; Preclinical; Enzyme Inhibitors; Protein Kinases; 药物设计; 酶抑制剂; 蛋白激酶类; 受体; 胞质和核;

机译：Drug Design;Drug Evaluation;Preclinical;Enzyme Inhibitors;Protein Kinases;药物设计;酶抑制剂;蛋白激酶类;受体;胞质和核;

相似文献

外文文献
中文文献
专利

1. Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization. [J] . Shuttleworth SJ, Connors RV, Fu J, Current medicinal chemistry . 2005,第11期

机译：设计和合成以蛋白质超家族为目标的化学文库，用于铅的鉴定和优化。
2. Chemical genetics: an evolving toolbox for target identification and lead optimization. [J] . Boshoff HI, Dowd CS Progress in drug research. . 2007,第0期

机译：化学遗传学：一个用于目标识别和潜在客户优化的不断发展的工具箱。
3. Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization. [J] . Decicco CP Bioorganic and Medicinal Chemistry Letters . 2003,第24期

机译：环状琥珀酸酯系列TNF-α转化酶抑制剂的合理设计，合成和构效关系。第2部分：销售线索优化。
4. Computer-Aided Library Design for Agrochemical Lead Generation: Design and Synthesis of Ring-Fused 2-Pyridinone Esters [C] . James M. Ruiz, Beth A. Lorsbach Pan-Pacific Conference on Pesticide Science . 2005

机译：用于农业化学铅发电的计算机辅助图书馆设计：环形融合2-吡啶酮酯的设计与合成
5. Part I. Design and synthesis of prototypes as leads on a compound library aimed at plasmepsin II inhibition. Part II. Synthesis and evaluation of modified nucleotides for DNA aptamer selection [D] . DiDonato, Dana A. 2006

机译：第一部分：原型的设计和合成，作为针对纤溶酶II抑制的化合物库上的先导。第二部分用于DNA适体选择的修饰核苷酸的合成和评估
6. Design and Synthesis of a Library of Lead-Like 24-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors [O] . Christian Schmitt, Dagmar Kail, Marica Mariano, -1

机译：铅样24-双环取代噻吩类化合物作为选择性Dyrk / Clk抑制剂的库的设计与合成
7. ABSTRACTudThe purpose of this research is to obtain an optimal formulations of Black mulberry leaves dried noodle product by using Design Expert Application with Design Mixture D-optimal method.udThis research was done with two phases. The preliminary procedures research is to determine levels of antioxidant activity, chlorophyll content, and the levels of tannin that was contained in black mulberry leaves, the black mulberry leaf flour, a pare fruits, and pare flour. Primary research is to determine the best formulation by using a Mixture Design Expert Design D-optimal method, for a purpose is to optimized the Black mulberry leaf dry noodle. Responses in this studies are a chemical analysis response by using a crude fiber analysis and protein analysis. Physical response is water absorption. Sensory response are color, flavor, and odor.udBlack mulberry leaves dried noodles was made from wheat flour, black mulberry leaf flour, and pare flour, other materials such as an eggs, water, salt, and sodium bicarbonate, of the 16 formulations that has offered to produce an optimal formulation based on desirability which contains 39.69 Flour,14.25 Black Mulberry Leaves flour, 3.06 Pare fruit and flour amounted, and other materials are 30 water, 10 eggs, 2 salt, and 1 sodium bicarbonate. The formulation has been result by program 11,05 crude fiber content, 12.93 protein, 274.31 water absorption, 4,31 for color attribute, 3,87 for taste attribute, and 3,71 for aroma attribute.ududKeyword: Black mulberry leaf dried noodles, optimization. [O] . Leti Nurlatifah Alumni, Yudi Garnida DS, Tantan Widiantara DS 2017

机译：抽象 ud本研究的目的是通过使用带有Design Mixture D-最优方法的Design Expert Application获得黑桑叶干面条产品的最佳配方。 ud这项研究分两个阶段进行。初步程序研究是确定抗氧化剂活性，叶绿素含量以及黑桑叶，黑桑叶粉，果皮和果皮中所含单宁的含量。首要研究是通过使用Mixture Design Expert Design D-optimal方法确定最佳配方，目的是优化黑桑叶干面条。本研究中的反应是通过使用粗纤维分析和蛋白质分析进行的化学分析反应。物理反应是吸水。感官反应是颜色，味道和气味。黑桑叶干面条由小麦粉，黑桑叶粉和削皮粉，鸡蛋，水，盐和碳酸氢钠等其他材料制成，这16种配方可根据需要提供最佳配方其中包含39.69％的面粉，14.25％的黑桑叶面粉，3.06％的去皮水果和面粉，其他材料是30％的水，10％的鸡蛋，2％的盐和1％的碳酸氢钠。该配方是通过程序11,05％的粗纤维含量，12.93％的蛋白质，274.31％的吸水率，4.31的颜色属性，3,87的味道属性和3,71的芳香属性得出的。 ud关键字：黑桑叶干面条，优化。

Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization.

摘要

著录项

相似文献

相关主题

期刊订阅