The centrifugal partition reactor, a novel intensified continuous reactor for liquid-liquid enzymatic reactions

摘要

Implementation of continuous processes for production of fine chemicals and pharmaceuticals is an efficient way for process intensification. This study aims at demonstrating the potential of a Centrifugal Partition Chromatography (CPC) apparatus as a novel type of intensified reactor (termed Centrifugal Partition Reactor, CPR) for biphasic (water-organic solvent) enzymatic reactions. The reaction of esterification of oleic acid with n-butanol catalyzed by the Rhizomucor miehei lipase was tested as the model reaction.