A randomized study to compare the efficacy and safety of extended-release and immediaterelease tramadol HCl/acetaminophen in patients with acute pain following total knee replacement

Park Yong-Beom; Ha Chul-Won; Cho Sung-Do; Lee Myung-Chul; Lee Ju-Hong; Seo Seung-Suk; Kang Seung-Baik; Kyung Hee-Soo; Choi Choong-Hyeok; Chang NaYoon; Rhim Hyou Young (Helen); Bin Seong-Il

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A randomized study to compare the efficacy and safety of extended-release and immediaterelease tramadol HCl/acetaminophen in patients with acute pain following total knee replacement

机译：一项随机研究比较了全膝关节置换术后急性疼痛患者中缓释和曲马多盐酸盐/对乙酰氨基酚的疗效和安全性

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Objective: To evaluate the relative efficacy and safety of extended-release tramadol HCl 75 mg/acetaminophen 650 mg (TA-ER) and immediate-release tramadol HCl 37.5 mg/acetaminophen 325 mg (TA-IR) for the treatment of moderate to severe acute pain following total knee replacement.

机译：目的：评估缓释曲马多HCl 75 mg /对乙酰氨基酚650 mg（TA-ER）和速释曲马多HCl 37.5 mg /对乙酰氨基酚325 mg（TA-IR）的相对疗效和安全性全膝关节置换术后出现急性疼痛。

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《Current medical research and opinion》 |2015年第1期|共10页
作者
Park Yong-Beom; Ha Chul-Won; Cho Sung-Do; Lee Myung-Chul; Lee Ju-Hong; Seo Seung-Suk; Kang Seung-Baik; Kyung Hee-Soo; Choi Choong-Hyeok; Chang NaYoon; Rhim Hyou Young (Helen); Bin Seong-Il;
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正文语种 eng
中图分类医药、卫生;
关键词
Acute pain; Pain intensity; Pain relief; Postoperative pain;

机译：急性疼痛;疼痛强度;疼痛缓解;术后疼痛;

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1. A randomized study to compare the efficacy and safety of extended-release and immediaterelease tramadol HCl/acetaminophen in patients with acute pain following total knee replacement [J] . Park Yong-Beom, Ha Chul-Won, Cho Sung-Do, Current medical research and opinion . 2015,第1期

机译：一项随机研究比较了全膝关节置换术后急性疼痛患者中缓释和曲马多盐酸盐/对乙酰氨基酚的疗效和安全性
2. A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of the extended-release tramadol hydrochloride/acetaminophen fixed-dose combination tablet for the treatment of chronic low back pain [J] . HyupLeeJ., LeeC.-S. Clinical therapeutics . 2013,第11期

机译：随机，双盲，安慰剂控制，并联研究，以评估盐酸延长型曲马多/乙酰氨基酚固定剂组合片剂的疗效和安全性用于治疗慢性低腰痛
3. Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled study. [J] . Altman RD, Zinsenheim JR, Temple AR, Osteoarthritis and cartilage . 2007,第4期

机译：对乙酰氨基酚缓释对髋部或膝盖骨关节炎疼痛的三个月疗效和安全性：一项随机，双盲，安慰剂对照研究。
4. Gamified Rehabilitation for Pain Distraction in Total-Knee-Replacement Patients [C] . Xuejiao Zhao, Qiong Wu, Yang Qiu, ACM Conference on Human Factors in Computing Systems . 2018

机译：在全膝置换患者中疼痛分心的赌博康复
5. The efficacy of hip strengthening exercises compared to leg strengthening exercises on knee pain, function and quality of life in patients with knee osteoarthritis. [D] . Marsh, Andrew David. 2010

机译：与腿部强化锻炼相比，髋部强化锻炼在膝关节骨关节炎患者中在膝关节疼痛，功能和生活质量方面的功效。
6. Patient directed self management of pain (PaDSMaP) compared to treatment as usual following total knee replacement: study protocol for a randomized controlled trial [O] . Simon Donell, Katherine Deane, Louise Swift, 2012

机译：全膝关节置换术后与常规治疗相比患者指导的自我疼痛管理（PaDSMaP）：一项随机对照试验的研究方案
7. Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled study [O] . Altman R.D., Zinsenheim J.R., Temple A.R., 2007

机译：对乙酰氨基酚缓释对髋部或膝盖骨关节炎疼痛的三个月疗效和安全性：一项随机，双盲，安慰剂对照研究

A randomized study to compare the efficacy and safety of extended-release and immediaterelease tramadol HCl/acetaminophen in patients with acute pain following total knee replacement

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