Palladium-Catalysed Chemo- and Regioselective C-H Bond Acylation of Pyridine N-Oxides with Benzyl Halides and Alcohols

摘要

A palladium-catalysed method for the acylation of ortho C-H bonds of pyridine N-oxides using readily available benzyl halides and benzyl alcohols as the active acylating agents is described. This procedure provides a new approach to 2-acylpyridine N-oxides, which may be used as precursors for the synthesis of pharmaceuticals and agrochemicals.