Design, synthesis and pharmacological evaluation of N4,N6-disubstituted pyrimidine-4,6-diamine derivatives as potent EGFR inhibitors in non-small cell lung cancer

Zhang Yuan; Lv Handeng; Luo Lu; Xu Yong; Pan Yaqian; Wang Yuewu; Lin Han; Xiong Jianhua; Guo Ping; Zhang Jinsan; Li Xiaokun; Ye Faqing

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Design, synthesis and pharmacological evaluation of N4,N6-disubstituted pyrimidine-4,6-diamine derivatives as potent EGFR inhibitors in non-small cell lung cancer

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Design, synthesis and pharmacological evaluation of N4,N6-disubstituted pyrimidine-4,6-diamine derivatives as potent EGFR inhibitors in non-small cell lung cancer

机译：N4，N6-二取代的嘧啶-4,6-二胺衍生物的设计，合成和药理学评价为非小细胞肺癌中有效的EGFR抑制剂

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2018年第2018期|共26页
作者
Zhang Yuan; Lv Handeng; Luo Lu; Xu Yong; Pan Yaqian; Wang Yuewu; Lin Han; Xiong Jianhua; Guo Ping; Zhang Jinsan; Li Xiaokun; Ye Faqing;
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Wenzhou Med Univ Sch Pharmaceut Sci Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharmaceut Sci Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharmaceut Sci Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharmaceut Sci Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharmaceut Sci Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharmaceut Sci Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Dept Pharm Affiliated Hosp 1 Wenzhou Peoples R China;

Wenzhou Peoples Hosp Wenzhou 325000 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharmaceut Sci Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharmaceut Sci Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharmaceut Sci Wenzhou 325035 Zhejiang Peoples R China;

Wenzhou Med Univ Sch Pharmaceut Sci Wenzhou 325035 Zhejiang Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
EGFR-TKIs; Scaffold hopping; NSCLC;

机译：EGFR-TKIS;脚手架跳跃;NSCLC;

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1. Design, synthesis and pharmacological evaluation of N4,N6-disubstituted pyrimidine-4,6-diamine derivatives as potent EGFR inhibitors in non-small cell lung cancer [J] . Zhang Yuan, Lv Handeng, Luo Lu, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2018,第期

机译：N4，N6-二取代的嘧啶-4,6-二胺衍生物的设计，合成和药理学评价为非小细胞肺癌中有效的EGFR抑制剂
2. Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer [J] . Zhu Wei, Chen Hui, Wang Yulan, Journal of Medicinal Chemistry . 2017,第14期

机译：新型多用户吡啶-3-胺衍生物的设计，合成和药理评估，作为多靶蛋白激酶抑制剂，用于治疗非小细胞肺癌
3. Design, synthesis and biological evaluation of novel 4-anlinoquinazoline derivatives as EGFR inhibitors with the potential to inhibit the gefitinib-resistant nonsmall cell lung cancers [J] . Caolin Wang, Shan Xu, Liang Peng, Journal of enzyme inhibition and medicinal chemistry. . 2019,第1期

机译：设计，合成和生物学评估作为EGFR抑制剂的新型4-anlinoquinazoline衍生物具有抑制吉非替尼耐药的非小细胞肺癌的潜力
4. Profiling EGFR Kinase Inhibitor Resistance Pathways in Non-Small Lung Cancer Cells [C] . Ryan D. Bomgarden, Ryan Jacobs, Jason Fong, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：在非小肺癌细胞中的谱分析EGFR激酶抑制剂抵抗途径
5. Pharmacological Evaluation of a Synthetic Coumarin Derivative (4-Fluorophenylacetamide-Acetyl Coumarin) for Its Potential Anticancer Activity in Non-Small Cell Lung Cancer Cell Line [D] . Umar, Shweta. 2020

机译：合成香豆素衍生物（4-氟苯乙酰胺 - 乙酰氨基甲酸）在非小细胞肺癌细胞系中抗癌活性的药理评价
6. Design synthesis and biological evaluation of novel 4-anlinoquinazoline derivatives as EGFR inhibitors with the potential to inhibit the gefitinib-resistant nonsmall cell lung cancers [O] . Caolin Wang, Shan Xu, Liang Peng, 2019

机译：设计合成和生物学评估作为EGFR抑制剂的新型4-anlinoquinazoline衍生物具有抑制吉非替尼耐药的非小细胞肺癌的潜力
7. Results of the non-small cell lung cancer part of a phase III, open-label, randomized trial evaluating topical corticosteroid therapy for facial acneiform dermatitis induced by EGFR inhibitors: stepwise rank down from potent corticosteroid (FAEISS study, NCCH-1512) [O] . Kazumi Nishino, Yutaka Fujiwara, Yuichiro Ohe, 2020

机译：EGFR抑制剂诱导的面部痤疮皮炎的非小细胞肺癌部分的非小细胞肺癌一部分的结果III，开放标签，随机试验评估局部皮质炎的局部皮质类固醇治疗：逐步排名从有效的皮质类固醇（FAEISS研究，NCCH-1512）

Design, synthesis and pharmacological evaluation of N4,N6-disubstituted pyrimidine-4,6-diamine derivatives as potent EGFR inhibitors in non-small cell lung cancer

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