Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities

摘要

Abstract A series of N-benzyl tetrahydropiperidinylidene pyrrolidinium salts have been synthesized and investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxic effects. The antibacterial, antimycobacterial and anticancer potencies of selected compounds were examined, too. Physicochemical parameters were calculated and structure-activity-relationships are discussed. Graphical abstract Display Omitted Highlights ? New N-benzyl tetrahydropyridinylidene salts were prepared and characterized. ? Their antiprotozoal, antibacterial and anticancer activities were investigated. ? Physicochemical parameters and structure-activity relationships are described. ? Few compounds show antibacterial properties and even in?vivo antimalarial activity.