Micro-homology-mediated end joining allows precise excision-insertion genome editing by a single adeno-associated virus vector to restore visual function in blind mice

Nishiguchi Koji M.; Fujita Kosuke; Katayama Shota; Nakazawa Toru

首页> 外文期刊>Investigative ophthalmology & visual science >Micro-homology-mediated end joining allows precise excision-insertion genome editing by a single adeno-associated virus vector to restore visual function in blind mice

【24h】

Micro-homology-mediated end joining allows precise excision-insertion genome editing by a single adeno-associated virus vector to restore visual function in blind mice

机译：微观介导的末端连接允许通过单个腺相关病毒载体进行精确的切除插入基因组，以恢复盲目小鼠的视觉功能

获取原文

获取原文并翻译 | 示例

获取外文期刊封面目录资料

开具论文收录证明 >>

文献代查 >>

文献数据库（团队版） >>

页面导航

著录项
引文网络
相似文献
相关主题

著录项

来源
《Investigative ophthalmology & visual science》 |2019年第9期|共2页
作者
Nishiguchi Koji M.; Fujita Kosuke; Katayama Shota; Nakazawa Toru;
展开▼
作者单位

Tohoku Univ Ophthalmol Sendai Miyagi Japan;

Tohoku Univ Ophthalmol Sendai Miyagi Japan;

Tohoku Univ Ophthalmol Sendai Miyagi Japan;

Tohoku Univ Ophthalmol Sendai Miyagi Japan;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类眼科学;
关键词

相似文献

外文文献
专利

1. Micro-homology-mediated end joining allows precise excision-insertion genome editing by a single adeno-associated virus vector to restore visual function in blind mice [J] . Nishiguchi Koji M., Fujita Kosuke, Katayama Shota, Investigative ophthalmology & visual science . 2019,第9期

机译：微观介导的末端连接允许通过单个腺相关病毒载体进行精确的切除插入基因组，以恢复盲目小鼠的视觉功能
2. Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx mice. [J] . Fabb SA, Wells DJ, Serpente P, Human Molecular Genetics . 2002,第7期

机译：144 kDa微量肌营养不良蛋白的腺相关病毒载体基因转移和肌膜表达可有效恢复肌营养不良蛋白相关蛋白复合物并抑制裸鼠/ mdx小鼠的肌纤维变性。
3. Adeno-associated virus vector (AAV) microdystrophin gene therapy prolongs survival and restores muscle function in the canine model of Duchenne muscular dystrophy (DMD) [J] . Le Guiner C., Servais L., Montus M., Neuromuscular disorders: NMD . 2015,第Suppla2期

机译：腺相关病毒载体（AAV）微量肌营养不良蛋白基因疗法延长了杜兴氏肌肉营养不良（DMD）犬模型的存活率并恢复了肌肉功能
4. Application of Precise Genome Editing Tools in the Zebrafish Model to Elucidate Protein Function with Regards to Developmental Phenotypes [D] . Welker, Jordan Michael 2019

机译：精确的基因组编辑工具在斑马鱼模型中的应用，以阐明与发育表型有关的蛋白质功能
5. ITR-Seq a next-generation sequencing assay identifies genome-wide DNA editing sites in vivo following adeno-associated viral vector-mediated genome editing [O] . Camilo Breton, Peter M. Clark, Lili Wang, 2020

机译：ITR-Seq是下一代测序测定法可在腺相关病毒载体介导的基因组编辑后在体内鉴定全基因组DNA编辑位点
6. Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx mice [O] . S. A. Fabb 2002

机译：Adeno相关病毒载体基因转移和144kDa微营养蛋白的Sarcolemmal表达有效地恢复营养不良蛋白相关的蛋白质复合物，并抑制裸/ MDX小鼠中的肌纤维变性

Micro-homology-mediated end joining allows precise excision-insertion genome editing by a single adeno-associated virus vector to restore visual function in blind mice

著录项

引文网络

相似文献

相关主题

期刊订阅