Local anaesthetic toxicity

摘要

Local anaesthetic toxicity has been a known complication of local anaesthetics since use began in 1884 and it continues to be a problem in modern medical practice. Local anaesthetic toxicity occurs due to raised plasma concentrations following high doses or inadvertent intravenous administration. The clinical manifestations of toxicity are generally neurological, cardiac or both in origin. Prevention is the best approach for toxicity, but in the event of its occurrence, lipid emulsion infusion has been recommended as part of the treatment algorithm.